Document Detail

Treatment of febrile granuloycytopenic cancer patients receiving antineoplastic therapy with a combination of carbenicillin, cefazolin and gentamicin.
MedLine Citation:
PMID:  6580369     Owner:  NLM     Status:  MEDLINE    
A three drug regimen of carbenicillin, cefazolin and gentamicin was used for the treatment of patients with solid tumors, who developed fever while granulocytopenic following chemotherapy. Thirty-five (8%) of 426 cancer patients receiving various combinations of antineoplastic chemotherapy qualified for the antibiotic treatment. Nine patients (26%) had bacteriologically confirmed infections, all with gram negative microorganisms. Twenty-four patients (69%) recovered and eleven (31%) died. All deaths occurred within five days of antibiotic therapy; in patients who recovered, the fever subsided within six days. Mortality was not influenced by the presence of a positive bacterial culture, age, or the cytotoxic agents used. It was, however, strongly related to metastatic spread: nine out of 14 patients with liver metastases (64%) died from the infection, while only two of 11 patients (18%) with other metastatic sites failed to respond to the antibacterial therapy. No death occurred in 10 patients who had local disease or received adjuvant therapy. This combined antibiotic therapy was as effective as reported for other combinations, with no serious side effects.
J Halpern; R Catane; T Sacks; Z Fuks
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicine     Volume:  14     ISSN:  0025-7850     ISO Abbreviation:  J Med     Publication Date:  1983  
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  7505566     Medline TA:  J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-202     Citation Subset:  IM    
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MeSH Terms
Agranulocytosis / chemically induced,  complications,  drug therapy*
Anti-Bacterial Agents / therapeutic use
Antineoplastic Combined Chemotherapy Protocols / adverse effects*
Carbenicillin / administration & dosage*
Cefazolin / administration & dosage*
Drug Therapy, Combination
Fever / drug therapy*,  etiology
Gentamicins / administration & dosage*
Middle Aged
Neoplasms / complications*,  drug therapy
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gentamicins; 25953-19-9/Cefazolin; 4697-36-3/Carbenicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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