Document Detail

Treatment of facial angiofibroma of tuberous sclerosis using cultured epithelial autografts.
MedLine Citation:
PMID:  16998334     Owner:  NLM     Status:  MEDLINE    
Treatment of facial angiofibroma of tuberous sclerosis is problematic, because the skin lesions involve entire dermis. Five patients aged from 14 to 33 (mean: 23.6) years old with angiofibroma of tuberous sclerosis were treated with cultured epithelial autografts between 1995 and 2004. The entire area of the facial lesions was excised using a razor to remove large nodules, and then the remaining lesions were further abraded to a rather deep layer of the dermis to smooth the skin and remove small nodules. Then a cultured autologous epithelium was grafted onto the wound. In all patients, epithelization was complete within 10 (mean: 9) days after the surgery. All patients were followed up for more than 6 months and showed neither depigmentation due to scar formation nor hypertrophic scars. In some patients, some pebbly regrowth had occurred at 5 years postoperatively, but the appearance was quite acceptable.
Keijiro Hori; Kazutaka Soejima; Motohiro Nozaki; Hiroyuki Sakurai; Masaki Takeuchi; Takashi Yamaki; Susumu Iwasaka; Taro Kono; Takashi Honda; Tsukasa Isago
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  57     ISSN:  0148-7043     ISO Abbreviation:  Ann Plast Surg     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-25     Completed Date:  2007-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  415-7     Citation Subset:  IM    
Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan.
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MeSH Terms
Angiofibroma / etiology,  surgery*
Epithelium / transplantation*
Facial Neoplasms / etiology,  surgery*
Tissue Culture Techniques
Transplantation, Autologous
Treatment Outcome
Tuberous Sclerosis / complications*

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