| Treatment of established prosthetic vascular graft infection with antibiotics preferentially concentrated in leukocytes. | |
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MedLine Citation:
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PMID: 3589979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of treating established vascular graft infections with rifampin and clindamycin (preferentially concentrated in leukocytes) and cefazolin (not concentrated in leukocytes) was studied in a canine model. Infrarenal aortic, 6 mm by 6 cm knitted Dacron double velour grafts were implanted and infected with 10(8) colony-forming units (CFU) of coagulase-positive Staphyloccus aureus organisms injected intravenously immediately after graft placement. Antibiotic therapy was instituted at 3 months postimplantation. Three groups were studied: (I) untreated controls (n = 3); (II) therapy with intravenous cefazolin 15 mg/kg/8 hr for 28 days (n = 7); and (III) combined therapy with intravenous rifampin 13 mg/kg/24 hr and intravenous clindamycin 13 mg/kg/8 hr for 28 days (n = 7). Grafts were removed for quantitative bacteriologic studies after the 28-day course of therapy. Two group I control grafts remained patent with 6.4 X 10(6) and 8.1 X 10(3) CFU S. aureus/gm of graft. The third control graft was thrombosed. Two group II animals demonstrated 1.6 X 10(7) and 2.3 X 10(5) CFU S. aureus organisms/gram of graft, respectively; the remaining five group II grafts were free of organisms. All group III grafts were sterile--a significant difference (p less than 0.05) from group I grafts. In this experimental model, established prosthetic graft infections were eradicated by intensive treatment with antibiotics preferentially concentrated in leukocytes. |
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Authors:
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T W Wakefield; D R Schaberg; C L Pierson; J A Bouffard; N A Petry; K D Nolan; S A Spaulding; W M Whitehouse; J C Stanley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Surgery Volume: 102 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 1987 Jul |
Date Detail:
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Created Date: 1987-07-23 Completed Date: 1987-07-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 8-14 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Vessel Prosthesis* Cefazolin / metabolism, therapeutic use Clindamycin / metabolism, therapeutic use* Disease Models, Animal Dogs Drug Therapy, Combination Female Leukocytes / metabolism* Rifampin / metabolism, therapeutic use* Staphylococcal Infections / drug therapy Surgical Wound Infection / drug therapy* |
| Chemical | |
Reg. No./Substance:
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13292-46-1/Rifampin; 18323-44-9/Clindamycin; 25953-19-9/Cefazolin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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