Document Detail


Treatment of enterocutaneous fistula in Crohn's Disease with adipose-derived stem cells: a comparison of protocols with and without cell expansion.
MedLine Citation:
PMID:  18696086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Expanded adipose-derived stem cells (ASC) have been shown to be effective in treating Crohn's patients with enterocutaneous fistulas. It is possible that unexpanded cells corresponding to the stromal vascular fraction (SVF) may also be effective. MATERIALS AND METHODS: A subpopulation of patients from a previous proof-of-concept phase I study with enterocutaneous fistulas received autologous expanded ASCs. The same selection criteria for inclusion were applied to patients who underwent SVF implantation to treat enterocutaneous fistulas. After tract curettage, cell suspensions (either SVF cells from lipoaspirate or expanded ASCs) were injected into the tract walls, and the fistulous tract was sealed with fibrin adhesive (with or without cells). RESULTS: In the series that received ASCs, four fistulas could be evaluated, and cure was achieved in three out of four cases. In the series that received SVF cells, four fistulas were evaluated, with cure achieved in one out of four cases. CONCLUSIONS: Although a comparison of case series cannot be considered firm evidence, a therapeutic protocol that uses expansion prior to implantation does seem to be more effective than one that uses SVF cells directly from a lipoaspirate sample.
Authors:
Damian Garcia-Olmo; Dolores Herreros; Maria Pascual; Isabel Pascual; Paloma De-La-Quintana; Jacobo Trebol; Mariano Garcia-Arranz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-12
Journal Detail:
Title:  International journal of colorectal disease     Volume:  24     ISSN:  0179-1958     ISO Abbreviation:  Int J Colorectal Dis     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607899     Medline TA:  Int J Colorectal Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  27-30     Citation Subset:  IM    
Affiliation:
Department of Surgery, La Paz University Hospital, Madrid, Spain. damian.garcia@uam.es
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / cytology*
Adult
Cell Separation
Crohn Disease / complications*
Female
Fibrin Tissue Adhesive / therapeutic use
Humans
Intestinal Fistula / etiology,  therapy*
Male
Middle Aged
Stem Cell Transplantation*
Stromal Cells / cytology
Tissue Adhesives / therapeutic use
Transplantation, Autologous
Wound Healing
Chemical
Reg. No./Substance:
0/Fibrin Tissue Adhesive; 0/Tissue Adhesives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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