| Treatment of enterocutaneous fistula in Crohn's Disease with adipose-derived stem cells: a comparison of protocols with and without cell expansion. | |
| | |
MedLine Citation:
|
PMID: 18696086 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Expanded adipose-derived stem cells (ASC) have been shown to be effective in treating Crohn's patients with enterocutaneous fistulas. It is possible that unexpanded cells corresponding to the stromal vascular fraction (SVF) may also be effective. MATERIALS AND METHODS: A subpopulation of patients from a previous proof-of-concept phase I study with enterocutaneous fistulas received autologous expanded ASCs. The same selection criteria for inclusion were applied to patients who underwent SVF implantation to treat enterocutaneous fistulas. After tract curettage, cell suspensions (either SVF cells from lipoaspirate or expanded ASCs) were injected into the tract walls, and the fistulous tract was sealed with fibrin adhesive (with or without cells). RESULTS: In the series that received ASCs, four fistulas could be evaluated, and cure was achieved in three out of four cases. In the series that received SVF cells, four fistulas were evaluated, with cure achieved in one out of four cases. CONCLUSIONS: Although a comparison of case series cannot be considered firm evidence, a therapeutic protocol that uses expansion prior to implantation does seem to be more effective than one that uses SVF cells directly from a lipoaspirate sample. |
| | |
Authors:
|
Damian Garcia-Olmo; Dolores Herreros; Maria Pascual; Isabel Pascual; Paloma De-La-Quintana; Jacobo Trebol; Mariano Garcia-Arranz |
Related Documents
:
|
19575556 - How sweet it is! cell wall biogenesis and polysaccharide capsule formation in cryptococ... 880206 - Gelation of the amoebocyte lysate of tachypleus tridentatus by cell wall digest of seve... 2271766 - A computer simulation of the creep process of the cell wall using stress relaxation par... 3897066 - Measurement of streptococcal cell wall in tissues of rats resistant or susceptible to c... 1980036 - Mutagenic and teratogenic effects of cyclophosphamide on the chick embryo: chromosomal ... 1282196 - Monoclonal antibodies against human alpha-fetoprotein more reactive to cell-surface alp... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-12 |
Journal Detail:
|
Title: International journal of colorectal disease Volume: 24 ISSN: 0179-1958 ISO Abbreviation: Int J Colorectal Dis Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2008-11-26 Completed Date: 2009-03-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8607899 Medline TA: Int J Colorectal Dis Country: Germany |
Other Details:
|
Languages: eng Pagination: 27-30 Citation Subset: IM |
Affiliation:
|
Department of Surgery, La Paz University Hospital, Madrid, Spain. damian.garcia@uam.es |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue
/
cytology* Adult Cell Separation Crohn Disease / complications* Female Fibrin Tissue Adhesive / therapeutic use Humans Intestinal Fistula / etiology, therapy* Male Middle Aged Stem Cell Transplantation* Stromal Cells / cytology Tissue Adhesives / therapeutic use Transplantation, Autologous Wound Healing |
| Chemical | |
Reg. No./Substance:
|
0/Fibrin Tissue Adhesive; 0/Tissue Adhesives |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Referral patterns of patients with liver metastases due to colorectal cancer for resection.
Next Document: Reinterventions after complicated or failed STARR procedure.