| Treatment effects on the total ischaemic burden and prognostic implications. | |
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MedLine Citation:
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PMID: 8960459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anginal symptoms alone are not a reliable guide to the extent of patients' ischaemic heart disease and silent episodes of ischaemia are associated with increased morbidity and mortality. It is becoming apparent that effective treatment of ischaemia will have to target the pattern of ischaemic events seen in patients' daily lives and treatment strategies are now being developed which aim to eliminate both silent and symptomatic episodes of ischaemia over the whole 24-h period. For example, the Circadian Anti-ischaemia Program in Europe (CAPE) trial has shown that significant improvements in objective and subjective measures of ischaemia occurred over 24 h when the once-daily third-generation dihydropyridine calcium antagonist amlodipine was added to background medical therapy. In addition, the Canadian Amlodipine/Atenolol in Silent Ischaemia Study (CASIS) has clearly shown the complementary effects of combination therapy with amlodipine and the long-acting beta-blocker atenolol. Ongoing and future outcome studies will determine the impact of such approaches on the prognosis for patients with ischaemic heart disease. |
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Authors:
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J Deanfield |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: European heart journal Volume: 17 Suppl G ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-03-13 Completed Date: 1997-03-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 64-8 Citation Subset: IM |
Affiliation:
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Great Ormond Street Hospital for Children, London, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amlodipine
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therapeutic use* Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Calcium Channel Blockers / therapeutic use* Clinical Trials as Topic Electrocardiography, Ambulatory Humans Myocardial Ischemia / diagnosis, drug therapy*, physiopathology Prognosis Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Calcium Channel Blockers; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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