| Treatment effects of stimulant medication in young boys with fragile X syndrome. | |
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MedLine Citation:
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PMID: 21671049 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and is caused by a CGG repeat expansion at Xq27.3 on the FMR1 gene. The majority of young boys with FXS display poor attention and hyperactivity that is disproportionate to their cognitive disability, and approximately 70% meet diagnostic criteria for attention-deficit/hyperactivity disorder. Psychopharmacology is employed with 82% of young males 5-17 years of age, with stimulant medication as the most common medication prescribed. This study evaluated the effects of stimulant medication on the academic performance, attention, motor activity, and psychophysiological arousal of boys with FXS, as well as the concordance of effects within individuals. Participants in this study included 12 boys with FXS who were treated with stimulants. Participants completed videotaped academic testing on two consecutive days and were randomly assigned to be off stimulants for 1 day and on stimulants the other day. On each day, multiple measures including academic performance, behavior regulation, and psychophysiological arousal were collected. Approximately 75% of participants performed better on attention and academic measures, and 70% showed improved physiological regulation while on stimulant medication. A high degree of concordance among measures was found. Lower intelligence quotient (IQ), but not age, correlated with greater improvements in in-seat behavior. IQ and age did not relate to on-task behaviors. The frequency and magnitude of response to stimulant medication in boys with FXS is higher than those reported for most children with non-specific intellectual disabilities and autism spectrum disorder. |
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Authors:
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Jane E Roberts; Margot Miranda; Maria Boccia; Heather Janes; Bridgette L Tonnsen; Deborah D Hatton |
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Publication Detail:
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Type: Journal Article Date: 2011-06-14 |
Journal Detail:
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Title: Journal of neurodevelopmental disorders Volume: 3 ISSN: 1866-1955 ISO Abbreviation: J Neurodev Disord Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-06 Completed Date: 2011-11-10 Revised Date: 2012-01-20 |
Medline Journal Info:
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Nlm Unique ID: 101483832 Medline TA: J Neurodev Disord Country: United States |
Other Details:
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Languages: eng Pagination: 175-84 Citation Subset: - |
Affiliation:
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Department of Psychology, University of South Carolina, 1512 Pendleton Street, Columbia, SC, 29028, USA, jerobert@mailbox.sc.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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