| Treatment effects of maternal micronutrient supplementation vary by percentiles of the birth weight distribution in rural Nepal. | |
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MedLine Citation:
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PMID: 16614435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Certain antenatal micronutrient supplements increased birth weight by 40-70 g in rural Nepal. The effect was estimated by calculating the mean difference in birth weight between control and treatment groups, which assumes a constant treatment effect across the birth weight distribution. By estimating differences (and CI) in birth weight between treatment and control groups as a nonlinear, smooth function of the percentiles of the birth weight distribution, we can examine whether the shape of the birth weight distribution for a treatment group is different from that of the control group. Supplementation groups were folic acid, folic acid and iron, folic acid and iron and zinc, and a multiple micronutrient supplement all with vitamin A, compared with the control group of vitamin A alone. The shape of the birth weight distribution in the multiple micronutrient group was the same as that of the control group; however, the location of the distribution had shifted. The folic acid and iron group had fewer infants in the lower tail of its distribution but a similar proportion in the upper tail compared with the control group. The biologic pathways affecting intrauterine growth may vary by micronutrients such that some may confer a benefit among the most vulnerable infants, whereas others may have a more constant effect across the birth weight distribution. Future analytic approaches to estimating benefits of maternal supplementation on birth weight should examine whether there is a constant or variable treatment effect across the distribution of birth weight. |
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Authors:
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Joanne Katz; Parul Christian; Francesca Dominici; Scott L Zeger |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of nutrition Volume: 136 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-14 Completed Date: 2006-06-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1389-94 Citation Subset: IM |
Affiliation:
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Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205-2103, USA. jkatz@jhsph.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Birth Weight* Body Height Body Weight Child Dietary Supplements* Female Gestational Age Humans Infant Infant, Newborn Maternal Age Micronutrients / pharmacology* Nepal Pregnancy Prenatal Care Rural Population Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Micronutrients |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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