Document Detail

Treatment effects of maternal micronutrient supplementation vary by percentiles of the birth weight distribution in rural Nepal.
MedLine Citation:
PMID:  16614435     Owner:  NLM     Status:  MEDLINE    
Certain antenatal micronutrient supplements increased birth weight by 40-70 g in rural Nepal. The effect was estimated by calculating the mean difference in birth weight between control and treatment groups, which assumes a constant treatment effect across the birth weight distribution. By estimating differences (and CI) in birth weight between treatment and control groups as a nonlinear, smooth function of the percentiles of the birth weight distribution, we can examine whether the shape of the birth weight distribution for a treatment group is different from that of the control group. Supplementation groups were folic acid, folic acid and iron, folic acid and iron and zinc, and a multiple micronutrient supplement all with vitamin A, compared with the control group of vitamin A alone. The shape of the birth weight distribution in the multiple micronutrient group was the same as that of the control group; however, the location of the distribution had shifted. The folic acid and iron group had fewer infants in the lower tail of its distribution but a similar proportion in the upper tail compared with the control group. The biologic pathways affecting intrauterine growth may vary by micronutrients such that some may confer a benefit among the most vulnerable infants, whereas others may have a more constant effect across the birth weight distribution. Future analytic approaches to estimating benefits of maternal supplementation on birth weight should examine whether there is a constant or variable treatment effect across the distribution of birth weight.
Joanne Katz; Parul Christian; Francesca Dominici; Scott L Zeger
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  136     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-14     Completed Date:  2006-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1389-94     Citation Subset:  IM    
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205-2103, USA.
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MeSH Terms
Birth Weight*
Body Height
Body Weight
Dietary Supplements*
Gestational Age
Infant, Newborn
Maternal Age
Micronutrients / pharmacology*
Prenatal Care
Rural Population
Weight Gain
Reg. No./Substance:

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