Document Detail

Treatment effects of alprazolam and imipramine: physiological versus subjective changes in patients with generalized anxiety disorder.
MedLine Citation:
PMID:  2268689     Owner:  NLM     Status:  MEDLINE    
The correspondence between changes in physiological activity and somatic symptom reports was assessed in generalized anxiety disorder patients treated with alprazolam or imipramine. After 6 weeks, the two medications produced comparable reductions in self-reported somatic symptoms. However, patients taking alprazolam showed decreases in systolic blood pressure, epinephrine, and norepinephrine, and patients taking imipramine showed increases in heart rate, blood pressure, electromyographic activity, and norepinephrine. Thus, though the physiological changes associated with alprazolam treatment were consistent with changes in symptom reports, treatment with imipramine produced a desynchrony: patients reported significant decreases in cardiovascular symptoms and muscle tension in spite of the fact that heart rate, blood pressure, and electromyographic activity increased. Possible explanations for this counterintuitive phenomenon are discussed.
D R McLeod; R Hoehn-Saric; W D Zimmerli; E B De Souza; L K Oliver
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biological psychiatry     Volume:  28     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-02-19     Completed Date:  1991-02-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  849-61     Citation Subset:  IM    
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
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MeSH Terms
Alprazolam / administration & dosage*
Anxiety Disorders / blood,  drug therapy*,  psychology
Arousal / drug effects*
Electromyography / drug effects
Epinephrine / blood
Heart Rate / drug effects
Imipramine / administration & dosage*
Middle Aged
Norepinephrine / blood
Personality Tests
Grant Support
Reg. No./Substance:
28981-97-7/Alprazolam; 50-49-7/Imipramine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

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