| Treatment effects of alprazolam and imipramine: physiological versus subjective changes in patients with generalized anxiety disorder. | |
| | |
MedLine Citation:
|
PMID: 2268689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The correspondence between changes in physiological activity and somatic symptom reports was assessed in generalized anxiety disorder patients treated with alprazolam or imipramine. After 6 weeks, the two medications produced comparable reductions in self-reported somatic symptoms. However, patients taking alprazolam showed decreases in systolic blood pressure, epinephrine, and norepinephrine, and patients taking imipramine showed increases in heart rate, blood pressure, electromyographic activity, and norepinephrine. Thus, though the physiological changes associated with alprazolam treatment were consistent with changes in symptom reports, treatment with imipramine produced a desynchrony: patients reported significant decreases in cardiovascular symptoms and muscle tension in spite of the fact that heart rate, blood pressure, and electromyographic activity increased. Possible explanations for this counterintuitive phenomenon are discussed. |
| | |
Authors:
|
D R McLeod; R Hoehn-Saric; W D Zimmerli; E B De Souza; L K Oliver |
Related Documents
:
|
1483799 - Treatment of high altitude diseases without drugs. 3570039 - Effect of aging on anorectal function. 15750259 - Valsartan in elderly isolated systolic hypertension (valish) study: rationale and design. 3384519 - Cardiovascular response during upright isometric dead lift in young, older, and elderly... 15549479 - Performance of a tonometer for arterial pressure measurement during anesthesia in the e... 2710909 - Behavioral treatment of essential hypertension: a comparison between cognitive therapy ... 16497109 - Systemic blood pressure response to the inhibition of two hyperpolarizing pathways: a c... 12147929 - Essential hypertension of caribbean hispanics: sodium, renin, and response to therapy. 22627959 - Re-expansion pulmonary edema in a patient with total pneumothorax: a hazardous outcome. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Biological psychiatry Volume: 28 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 1990 Nov |
Date Detail:
|
Created Date: 1991-02-19 Completed Date: 1991-02-19 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 849-61 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alprazolam / administration & dosage* Anxiety Disorders / blood, drug therapy*, psychology Arousal / drug effects* Electromyography / drug effects Epinephrine / blood Female Heart Rate / drug effects Humans Imipramine / administration & dosage* Male Middle Aged Norepinephrine / blood Personality Tests |
| Grant Support | |
ID/Acronym/Agency:
|
MH35435/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
28981-97-7/Alprazolam; 50-49-7/Imipramine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Observations on the metabolism of the psychotomimetic indolealkylamines: implications for future cli...
Next Document: Ontogeny of selective attention effects on event-related potentials in attention-deficit hyperactivi...