Document Detail


Treatment effects of GnRH agonist on the binding of estrogen and progesterone, and the histological findings of uterine leiomyomas.
MedLine Citation:
PMID:  1724899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The changes in the histology and steroid hormone binding capacity of the uterine leiomyomas treated with; GnRH agonists (GnRHa buserelin acetate in, 900 micrograms/day for 16 weeks) were investigated. The occurrence of hyaline degeneration in the myometrium was significantly higher in the GnRHa-treated group than in the control group, and the grade of hyaline degeneration was more advanced in the GnRHa group. After the GnRHa treatment, the Bmax of the estrogen receptor increased significantly in the leiomyomas and myometrium. The Bmax of progesterone receptors in the myometrium decreased significantly and the reduction rates of leiomyomas (% of the initial volumes) measured by MRI correlated (r = 0.775) with the Bmax of progesterone receptors. In summary, GnRHa caused hyaline degeneration of the uterine leiomyomas which were responsible for the shrinkage. The shrunk leiomyomas have the potential for regrowth in response to estrogen as they still have high concentrations of the estrogen receptors.
Authors:
T Uemura; J Mori; Y Yoshimura; H Minaguchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asia-Oceania journal of obstetrics and gynaecology / AOFOG     Volume:  17     ISSN:  0389-2328     ISO Abbreviation:  Asia Oceania J Obstet Gynaecol     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-04-20     Completed Date:  1992-04-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102781     Medline TA:  Asia Oceania J Obstet Gynaecol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  315-20     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Yokohama City University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Buserelin / pharmacology*
Female
Humans
Hyalin / drug effects
Leiomyoma / drug therapy*,  metabolism,  pathology
Receptors, Estrogen / drug effects,  metabolism
Receptors, Progesterone / drug effects,  metabolism
Uterine Neoplasms / drug therapy*,  metabolism,  pathology
Chemical
Reg. No./Substance:
0/Receptors, Estrogen; 0/Receptors, Progesterone; 57982-77-1/Buserelin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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