| Treatment of early infectious syphilis with N,N'-dibenzylethylenediamine dipenicillin G; a second report. | |
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MedLine Citation:
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PMID: 13182589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new penicillin salt-N,N'-dibenzylethylenediamine dipenicillin G (Bicillin)(a)-was given, in single injections of 2,500,000 units, to 196 patients with early infectious syphilis. The seronegativity rates after three months were 65% for primary syphilis cases and 25% for secondary syphilis patients; after six months, the rates were 80% and 60%, respectively. At the end of the 21-month observation period, satisfactory results were recorded in 96.6%-100.0% of the primary syphilis patients, and in 92%-95% of those treated for secondary syphilis. The respective cumulative re-treatment rates were 3.4% and 4.1%.The results of the secondary syphilis treatment were then compared with those obtained with single-injection schedules of 2,400,000 and 4,800,000 units of procaine penicillin G in oil with 2% aluminium monostearate (PAM). The cumulative re-treatment rates 21 months after treatment were: Bicillin, 4.1%; PAM (2.4 million units), 14.2%; and PAM (4.8 million units), 5.1%. It would thus appear that a single injection of 2,500,000 units of Bicillin is as effective as one of 4,800,000 units of PAM. |
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Authors:
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J K SHAFER; C A SMITH |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bulletin of the World Health Organization Volume: 10 ISSN: 0042-9686 ISO Abbreviation: Bull. World Health Organ. Publication Date: 1954 |
Date Detail:
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Created Date: 1954-12-01 Completed Date: 2003-05-01 Revised Date: 2010-10-26 |
Medline Journal Info:
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Nlm Unique ID: 7507052 Medline TA: Bull World Health Organ Country: Not Available |
Other Details:
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Languages: eng Pagination: 619-26 Citation Subset: OM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Penicillins
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analogs & derivatives* Syphilis / therapy* |
| Chemical | |
Reg. No./Substance:
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0/Penicillins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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