Document Detail

Treatment of dural sinus thrombosis using selective catheterization and urokinase.
MedLine Citation:
PMID:  7611726     Owner:  NLM     Status:  MEDLINE    
Thrombosis of the cerebral dural venous sinuses, cortical draining veins, and deep cerebral veins is a rare clinical finding. Because of its low incidence and multiple etiologies, the optimum therapy for this condition will only be elucidated by a multicenter, randomized prospective study. At our institution, we favor early and aggressive management of cerebral venous sinus thrombosis with transfemoral, venous intradural infusions of the fibrinolytic agent urokinase. To date, treatment of only 13 patients using this technique has been reported in the English literature. This report adds 12 more such treated patients. Despite the presence of preinfusion infarcts in 5 patients, four of which were hemorrhagic, we incurred no major therapeutic morbidity. Functional sinus patency was achieved in 11 of 12 patients, with our only true failure occurring in an individual with symptoms of at least 2 months' duration. Good to excellent clinical outcome was achieved in 10 of 11 patients (one newborn had inadequate follow-up).
M Horowitz; P Purdy; H Unwin; G Carstens; R Greenlee; J Hise; T Kopitnik; H Batjer; N Rollins; D Samson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  38     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-08-16     Completed Date:  1995-08-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  58-67     Citation Subset:  IM    
Department of Radiology, University of Texas Southwestern Medical Center at Dallas 75235-8896, USA.
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MeSH Terms
Brain / radiography
Cerebral Angiography
Dura Mater / blood supply*
Magnetic Resonance Imaging
Sinus Thrombosis, Intracranial / drug therapy*,  radiography
Thrombolytic Therapy*
Tomography, X-Ray Computed
Urokinase-Type Plasminogen Activator / therapeutic use
Reg. No./Substance:
EC Plasminogen Activator

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