| Treatment of duodenitis with cimetidine: a clinical, endoscopic, and histologic study. | |
| | |
MedLine Citation:
|
PMID: 2266237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We studied the effectiveness of cimetidine in the treatment of endoscopically diagnosed duodenitis. Sixty-nine patients with the solitary endoscopic finding of duodenitis (6% of 1,200 patients who underwent fiberoptic endoscopy of the upper gastrointestinal tract in our unit over 3 years) were studied retrospectively: a good clinical response was apparent in 45 of 69 patients treated with cimetidine (65%), and a fair response in another four (6%). In a controlled, randomized prospective study, we evaluated the effectiveness of cimetidine in duodenitis. Statistically significant improvement for the clinical and endoscopic scores was found in 10 patients treated with cimetidine (p less than 0.01). Improvement in the histologic score did not reach statistical significance. No such improvement was demonstrated in seven placebo-treated patients. We believe that duodenitis is a "peptic syndrome," has a good response to cimetidine treatment, and behaves much like duodenal ulcer disease. |
| | |
Authors:
|
Y Niv; S Abu-Avid; T Chana |
Related Documents
:
|
6519637 - Relapse rates of duodenal ulcer healed with concentrated antacid or cimetidine. 1882907 - Comparative study of sucralfate 2 grams twice daily versus sucralfate 1 gram four times... 6108607 - Treatment of duodenal ulcer with ranitidine, a new histamine h2-receptor antagonist. 35197 - Review of clinical studies on clobazam. 21704887 - Persistence of effectiveness of bronchial thermoplasty in patients with severe asthma. 23432777 - Polylactic acid vs. polyacrylamide hydrogel for treatment of facial lipoatrophy: a rand... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Journal of clinical gastroenterology Volume: 12 ISSN: 0192-0790 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 1990 Dec |
Date Detail:
|
Created Date: 1991-02-13 Completed Date: 1991-02-13 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 628-32 Citation Subset: IM |
Affiliation:
|
Gastroenterology Unit, Rebecca Sieff Government Hospital, Safed, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cimetidine / therapeutic use* Double-Blind Method Duodenitis / drug therapy*, pathology Duodenoscopy Female Humans Male Middle Aged Prospective Studies Retrospective Studies |
| Chemical | |
Reg. No./Substance:
|
51481-61-9/Cimetidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Is gastric acid responsible for the pain in patients with essential dyspepsia?
Next Document: Colonic volvulus as a complication of celiac sprue.