Document Detail

Treatment of diffuse metastatic cancer pain by instillation of alcohol into the sella turcica.
MedLine Citation:
PMID:  319706     Owner:  NLM     Status:  MEDLINE    
The technique of "chemical hypophysectomy" was modified for the management of pain due to metastatic cancer. Using stereotaxic control, a needle is introduced via the nose into the sella turcica. Absolute alcohol is then injected into the pituitary. Of 13 patients who had severe uncontrollable pain, 11 obtained marked symptomatic relief. The longest follow-up period to date is seven months, with results persisting. Sequelae are those associated with destruction of the pituitary gland, the most significant being diabetes insipidus. Several cerebrospinal fluid leaks prompted us routinely to instill alpha-ethyl cyanoacrylate to seal the sella floor. Three patients had slight extraocular nerve palsies. There was no death related to the procedure.
J Katz; A B Levin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesiology     Volume:  46     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-03-15     Completed Date:  1977-03-15     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  115-21     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthesia, Spinal / instrumentation
Breast Neoplasms / drug therapy
Cerebrospinal Fluid Rhinorrhea / etiology
Ethanol / administration & dosage*
Kidney Neoplasms / drug therapy
Neoplasm Metastasis*
Pain, Intractable / drug therapy*
Postoperative Complications / etiology
Prostatic Neoplasms / drug therapy
Sella Turcica / drug effects*,  radiography
Stereotaxic Techniques / instrumentation
Uterine Cervical Neoplasms / drug therapy
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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