| Treatment of diffuse metastatic cancer pain by instillation of alcohol into the sella turcica. | |
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MedLine Citation:
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PMID: 319706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The technique of "chemical hypophysectomy" was modified for the management of pain due to metastatic cancer. Using stereotaxic control, a needle is introduced via the nose into the sella turcica. Absolute alcohol is then injected into the pituitary. Of 13 patients who had severe uncontrollable pain, 11 obtained marked symptomatic relief. The longest follow-up period to date is seven months, with results persisting. Sequelae are those associated with destruction of the pituitary gland, the most significant being diabetes insipidus. Several cerebrospinal fluid leaks prompted us routinely to instill alpha-ethyl cyanoacrylate to seal the sella floor. Three patients had slight extraocular nerve palsies. There was no death related to the procedure. |
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Authors:
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J Katz; A B Levin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anesthesiology Volume: 46 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1977 Feb |
Date Detail:
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Created Date: 1977-03-15 Completed Date: 1977-03-15 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 115-21 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Spinal
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instrumentation Breast Neoplasms / drug therapy Cerebrospinal Fluid Rhinorrhea / etiology Ethanol / administration & dosage* Female Humans Kidney Neoplasms / drug therapy Male Neoplasm Metastasis* Pain, Intractable / drug therapy* Postoperative Complications / etiology Prostatic Neoplasms / drug therapy Recurrence Sella Turcica / drug effects*, radiography Stereotaxic Techniques / instrumentation Uterine Cervical Neoplasms / drug therapy |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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