| Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise. | |
| | |
MedLine Citation:
|
PMID: 21718306 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background and purpose: Depression is the most common psychiatric disorder in Huntington's disease (HD) patients. Women are more prone to develop depression and such susceptibility might be related to serotonergic dysregulation. Experimental approach: We performed tests of depression-related behaviors on female R6/1 HD mice that had been chronically treated with sertraline or provided with running-wheels. Functional assessments of 5-HT(1A) and 5-HT(2A) receptors were performed by measuring behavioral and physiological responses following administration of specific agonists, in combination with analysis of hippocampal gene expression. Finally we assessed the effect of exercise on hippocampal cell proliferation. Key results: Female HD mice recorded increased immobility time in the forced-swimming test, reduced saccharin preference and a hyperthermic response to stress compared to wild-type animals. These alterations were improved by chronic sertraline treatment. Wheel-running also resulted in similar improvements with the exception of saccharin preference while failing to correct the hippocampal cell proliferation deficits displayed by HD mice. The benefits of sertraline treatment and exercise involved altered 5-HT(1A) autoreceptor function as demonstrated by modulation of the exaggerated 8-OH-DPAT-induced hypothermia exhibited by female HD mice. On the other hand, sertraline treatment was unable to rescue the reduced 5-HT(1A) and 5-HT(2) heteroceptor function observed in HD animals. Conclusions and implications: We report for the first time a crucial role for 5-HT(1A) autoreceptor function in mediating the sex-specific depressive-like phenotype of female R6/1 HD mice. Our data further supports a differential effect of chronic sertraline treatment and exercise on hippocampal cell proliferation despite common behavioral benefits. |
| | |
Authors:
|
Thibault Renoir; Terence Y C Pang; Michelle S Zajac; Grace Chan; Xin Du; Leah Leang; Caroline Chevarin; Laurence Lanfumey; Anthony J Hannan |
Related Documents
:
|
22347866 - Exercise as a potential treatment for drug abuse: evidence from preclinical studies. 8006296 - Glycolysis abnormalities in fibromyalgia. 6264886 - Lumbosacral radioculopathy: review of 100 consecutive cases. 16919056 - Myofascial trigger points, neck mobility and forward head posture in unilateral migraine. 12130606 - Randomised factorial trial of falls prevention among older people living in their own h... 2759936 - Effect of cerebrospinal fluid hyperosmolality on sweating in the heat-stressed patas mo... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-30 |
Journal Detail:
|
Title: British journal of pharmacology Volume: - ISSN: 1476-5381 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-7-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society. |
Affiliation:
|
Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne, Parkville, Australia; Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia; Inserm UMR S894 -F-75013 Paris, France; UPMC, Univ Paris 06, UMR S894, F-75013 Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR...
Next Document: 17(R)-resolvin D1 specifically inhibits TRPV3 leading to peripheral antinociception.