Document Detail

Treatment of depression associated with age-related macular degeneration: A double-blind, randomized, controlled study.
MedLine Citation:
PMID:  22073385     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Depression is frequently found in patients with age-related macular degeneration (AMD). The purpose of this study was to assess the effectiveness of escitalopram in treating major and minor depression in AMD patients.
METHODS: We conducted a crossover, randomized, double-blind, placebo-controlled, 16-week study comparing escitalopram with placebo. Inclusion criteria included reduced vision from AMD and major or minor depression, with a 17-item Hamilton Rating Scale for Depression (HAMD-17) score of ≥10. Participants were randomly assigned to receive either escitalopram or placebo for 8 weeks and then crossed over to the other treatment. The primary outcome was change on the total HAMD-17 score with escitalopram treatment compared with placebo.
RESULTS: We enrolled 16 AMD patients (mean age 79.1), 12 with major depression and 4 with minor depression. Mean HAMD-17 score at enrollment was 16.1 ± 4.2, and mean visual acuity in the better eye was 20/70. During escitalopram treatment, participants showed a significant reduction in HAMD-17 scores compared with placebo treatment (P = .01).
CONCLUSIONS: These findings suggest escitalopram may be an effective treatment f.
Barbara L Brody; Linda C Field; Anne-Catherine Roch-Levecq; Christine Y Moutier; Steven D Edland; Stuart I Brown
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists     Volume:  23     ISSN:  1547-3325     ISO Abbreviation:  Ann Clin Psychiatry     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911021     Medline TA:  Ann Clin Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-84     Citation Subset:  IM    
Department of Ophthalmology, Department of Family and Preventive Medicine (SDE, Division of Biostatistics), University of California, San Diego, La Jolla, CA USA. E-mail:
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