| Treatment of depressed tinnitus patients with nortriptyline. | |
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MedLine Citation:
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PMID: 2817678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients disabled by tinnitus show a high prevalence of major depression. Furthermore, tinnitus produces patterns of disability similar to those produced by major depression. To explore further this link between tinnitus and depression, and to investigate the efficacy of treating depression in the treatment of tinnitus, a single-blind, placebo-washout, nonrandomized pilot study of the tricyclic antidepressant nortriptyline (hydrochloride) was undertaken in disabled tinnitus patients who also met diagnostic criteria for major depression. Nineteen patients began the study, two responded to placebo, and two dropped out prior to completion. Fourteen considered their tinnitus improved, and 12 chose to continue taking nortriptyline after the study. Depression severity decreased, on the average, by 65% (p less than .0001). Tinnitus loudness measured by audiometric matching decreased by a mean of 10 dB or 50% (p less than .02). Self-reports of tinnitus loudness and severity, somatic and psychologic symptoms, and psychosocial dysfunction all showed significant improvement with treatment. These results suggest that what initially appears to be an irreversible otologic disability in these patients may be in large part a reversible psychiatric disability. |
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Authors:
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M D Sullivan; R A Dobie; C S Sakai; W J Katon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of otology, rhinology, and laryngology Volume: 98 ISSN: 0003-4894 ISO Abbreviation: Ann. Otol. Rhinol. Laryngol. Publication Date: 1989 Nov |
Date Detail:
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Created Date: 1989-12-06 Completed Date: 1989-12-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0407300 Medline TA: Ann Otol Rhinol Laryngol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 867-72 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Depressive Disorder / diagnosis, drug therapy, etiology* Drug Evaluation Humans Middle Aged Nortriptyline / adverse effects, therapeutic use* Tinnitus / complications*, diagnosis, psychology |
| Chemical | |
Reg. No./Substance:
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72-69-5/Nortriptyline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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