| Treatment of deeply located acute intravascular thrombi with therapeutic ultrasound guided by diagnostic ultrasound and intravenous microbubbles. | |
| | |
MedLine Citation:
|
PMID: 16929017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: We sought to determine the added value of simultaneous imaging of intravenously infused microbubbles that are being used to dissolve an intravascular thrombus with therapeutic ultrasound (TUS). METHODS: In a chronic canine arteriovenous graft occluded by a thrombus, TUS (1 MHz) was applied through a 6-cm-thick tissue-mimicking phantom (measured mean +/- SD peak negative pressure through the phantom, 958 +/- 104 kPa) during an intravenous infusion of either saline (n = 6 occlusions) or lipid-encapsulated microbubbles (ImaRx Therapeutics, Inc, Tucson, AZ). Therapeutic ultrasound was intermittently applied during the microbubble infusion either at set time intervals (n = 6 occlusions) or when simultaneous diagnostic ultrasound (DUS) indicated a sustained presence of microbubbles (n = 12 occlusions). Success was defined as return of rapid flow within the graft (grade 3 flow). RESULTS: Diagnostic ultrasound showed microbubbles moving through small channels within the thrombus before angiographic evidence of flow in the graft. This guided the timing of TUS application better than using set time intervals. Angiographic clearance of the thrombus and restoration of grade 3 flow at 45 minutes of treatment were seen in 33% of deeply located thrombosed grafts treated with TUS at set time intervals and 92% of grafts treated with TUS guided by DUS (P < .001 compared with set time intervals). CONCLUSIONS: The use of TUS with intravenous microbubbles has a high success rate in recanalizing deeply located thrombosed arteriovenous grafts when performed with DUS guidance. |
| | |
Authors:
|
Jeane M Tsutsui; Feng Xie; Jason Johanning; John Lof; Brian Cory; Amming He; Lewis Thomas; Terry Matsunaga; Evan Unger; Thomas R Porter |
Related Documents
:
|
11448697 - Numerical and experimental models of post-operative realistic flows in stenosed coronar... 4052717 - Effect of stasis on the patency of microvenous grafts in avulsed rabbit femoral vessels. 9070177 - Boundary layer infusion of nitric oxide reduces early smooth muscle cell proliferation ... 160747 - Determination of blood flow through arteriovenous fistulae and shunts. 18051107 - Automatic segmentation of blood vessels from dynamic mri datasets. 12857407 - Engineering blood: synthetic substitutes from fluorinated compounds. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine Volume: 25 ISSN: 0278-4297 ISO Abbreviation: J Ultrasound Med Publication Date: 2006 Sep |
Date Detail:
|
Created Date: 2006-08-24 Completed Date: 2006-12-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8211547 Medline TA: J Ultrasound Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1161-8 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, 981165 Nebraska Medical Center, Omaha, 68198-1165 USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiography Animals Chi-Square Distribution Dogs Graft Occlusion, Vascular / therapy*, ultrasonography* Infusions, Intravenous Microbubbles* Phantoms, Imaging Statistics, Nonparametric Thrombosis / therapy*, ultrasonography* Ultrasonic Therapy* Ultrasonography, Interventional* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Translabial ultrasonography in the assessment of urethral diameter and intrinsic urethral sphincter ...
Next Document: Detection of bleeding in injured femoral arteries with contrast-enhanced sonography.