Document Detail

Treatment of cytomegalovirus retinopathy with ganciclovir.
MedLine Citation:
PMID:  2821464     Owner:  NLM     Status:  MEDLINE    
Ganciclovir is an experimental antiviral drug with activity against human cytomegalovirus (CMV). Forty patients with acquired immune deficiency syndrome (AIDS) and CMV retinopathy were treated with ganciclovir on a compassionate protocol basis. Initial treatment doses ranged from 5.0 to 14.0 mg/kg/day for 9 to 26 days. Signs of drug response were a halt to enlargement of lesions, decreased opacification of retinal tissue, and resolution of hemorrhage and vasculitis. Complete response was seen in 88% of patients and incomplete response was seen in 9%. Vision improved or remained stable in 88% of patients. Initial treatment did not eradicate live virus from the eye. To prevent reactivation of disease, 26 patients received low-dose maintenance therapy ranging from 1.5 to 7.5 mg/kg/day, once or twice daily, 3 to 7 days per week. Reactivation of disease developed for unknown reasons in 50% of patients on continuous, uninterrupted maintenance therapy for longer than 3 weeks. Reversible neutropenia, requiring cessation of treatment, developed in 30% of patients on initial treatment and in 38% of patients on maintenance therapy. Rhegmatogenous retinal detachment was a late complication in seven patients. By reducing or delaying visual loss, ganciclovir appears to be useful in the management of CMV retinopathy in patients with AIDS.
G N Holland; Y Sidikaro; A E Kreiger; D Hardy; M J Sakamoto; L M Frenkel; D J Winston; M S Gottlieb; Y J Bryson; R E Champlin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ophthalmology     Volume:  94     ISSN:  0161-6420     ISO Abbreviation:  Ophthalmology     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-11-06     Completed Date:  1987-11-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  815-23     Citation Subset:  IM; X    
UCLA Uveitis Center, Jules Stein Eye Institute, Los Angeles, CA 90024.
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications
Acyclovir / administration & dosage,  adverse effects,  analogs & derivatives*,  therapeutic use
Cytomegalovirus Infections / complications,  drug therapy*,  pathology,  physiopathology
Middle Aged
Neutropenia / chemically induced
Retina / pathology
Retinal Diseases / complications,  drug therapy*,  pathology,  physiopathology
Vision, Ocular
Reg. No./Substance:
59277-89-3/Acyclovir; 82410-32-0/Ganciclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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