Document Detail


Treatment of cutaneous T-cell lymphomas with TP-5. Evaluation of the clinical effect in 8 patients.
MedLine Citation:
PMID:  6198843     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eight patients with cutaneous T-cell lymphomas (6 patients with mycosis fungoides, 1 patient with Sézary's syndrome, 1 patient with low-grade malignant lymphoma, unclassified) were treated with TP-5, a synthetic pentapeptide having the same biologic activity as the thymic hormone thymopoietin. TP-5 was administered three times weekly at a dosage of 50 mg subcutaneously in 6 patients, 50 mg intravenously in 1 patient, and 100 mg subcutaneously in 1 patient. Clinical evaluation at the end of the trial disclosed improvement in 4 patients (2 patients with mycosis fungoides, 1 patient with Sézary's syndrome, 1 patient with low-grade malignant lymphoma, unclassified), deterioration in 3 patients with mycosis fungoides and no change in 1 patient with mycosis fungoides. As TP-5 evidently exerts some effect on cutaneous T-cell lymphomas, further investigations of its therapeutic potential in this group of diseases seem worthwhile.
Authors:
B Przybilla; G Burg; C Schmoeckel; O Braun-Falco
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  63     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1983  
Date Detail:
Created Date:  1984-03-21     Completed Date:  1984-03-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  524-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Clinical Trials as Topic
Female
Hormones / administration & dosage,  therapeutic use*
Humans
Lymphoma / drug therapy*
Male
Middle Aged
Mycosis Fungoides / drug therapy
Peptide Fragments / administration & dosage,  therapeutic use*
Sezary Syndrome / drug therapy
Skin Neoplasms / drug therapy*
T-Lymphocytes
Thymopentin
Thymopoietins / administration & dosage,  therapeutic use*
Thymus Hormones / therapeutic use*
Time Factors
Chemical
Reg. No./Substance:
0/Hormones; 0/Peptide Fragments; 0/Thymopoietins; 0/Thymus Hormones; 69558-55-0/Thymopentin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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