Document Detail


Treatment of coronary spastic angina with a statin in addition to a calcium channel blocker: a pilot study.
MedLine Citation:
PMID:  18594477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Combined therapy with a statin and a calcium channel blocker, which can improve lipid metabolism and reduce oxidative stress, may attenuate coronary vasoconstriction in patients with coronary spastic angina (CSA). After 6 months of therapy with benidipine and pravastatin, an acetylcholine provocation test was performed a second time in 25 patients with CSA. The patients were divided into 2 groups according to whether the result of this second test was positive (n = 13) or negative (n = 12). The test was designated as positive when the intracoronary injection of acetylcholine induced angiographically demonstrable total or subtotal occlusion (positive-test group). In the negative-test group, significant decrease in the plasma levels of low-density lipoprotein (LDL) cholesterol (-20.7 +/- 11.1%, P < 0.01 versus baseline) were observed along with a dramatic increase in the serum level of high-density lipoprotein (HDL) cholesterol (26.8 +/- 13.2%, P < 0.01 versus baseline). Furthermore, a significant decrease of the malondialdehyde-modified low-density lipoprotein (MDA-LDL) level, a marker of oxidative stress, was also observed (-22.6 +/- 14.1%, P < 0.01 versus baseline) in this group. In the positive-test group, however, no significant changes were found in any of the aforementioned parameters. The results showed that improvement of lipid metabolism, especially an increase of HDL cholesterol level and a reduction of MDA-LDL, may inhibit vascular contractility.
Authors:
Shigemasa Tani; Ken Nagao; Takeo Anazawa; Hirofumi Kawamata; Shingo Furuya; Hiroshi Takahashi; Kiyoshi Iida; Takeshi Fuji; Michiaki Matsumoto; Takamichi Kumabe; Yuichi Sato; Atsushi Hirayama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  52     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-22     Completed Date:  2008-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  28-34     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Nihon University Surugadai Hospital, Tokyo, Japan. tanishigem@yahoo.co.jp
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MeSH Terms
Descriptor/Qualifier:
Angina Pectoris, Variant / drug therapy*
Calcium Channel Blockers / therapeutic use*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Coronary Vasospasm / drug therapy*
Dihydropyridines / therapeutic use*
Drug Therapy, Combination
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Lipid Metabolism / drug effects
Lipoproteins, LDL / blood
Male
Malondialdehyde / analogs & derivatives,  blood
Middle Aged
Pilot Projects
Pravastatin / therapeutic use*
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dihydropyridines; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipoproteins, LDL; 0/malondialdehyde-low density lipoprotein, mouse; 105979-17-7/benidipine; 542-78-9/Malondialdehyde; 81093-37-0/Pravastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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