| Treatment of coronary spastic angina with a statin in addition to a calcium channel blocker: a pilot study. | |
| | |
MedLine Citation:
|
PMID: 18594477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Combined therapy with a statin and a calcium channel blocker, which can improve lipid metabolism and reduce oxidative stress, may attenuate coronary vasoconstriction in patients with coronary spastic angina (CSA). After 6 months of therapy with benidipine and pravastatin, an acetylcholine provocation test was performed a second time in 25 patients with CSA. The patients were divided into 2 groups according to whether the result of this second test was positive (n = 13) or negative (n = 12). The test was designated as positive when the intracoronary injection of acetylcholine induced angiographically demonstrable total or subtotal occlusion (positive-test group). In the negative-test group, significant decrease in the plasma levels of low-density lipoprotein (LDL) cholesterol (-20.7 +/- 11.1%, P < 0.01 versus baseline) were observed along with a dramatic increase in the serum level of high-density lipoprotein (HDL) cholesterol (26.8 +/- 13.2%, P < 0.01 versus baseline). Furthermore, a significant decrease of the malondialdehyde-modified low-density lipoprotein (MDA-LDL) level, a marker of oxidative stress, was also observed (-22.6 +/- 14.1%, P < 0.01 versus baseline) in this group. In the positive-test group, however, no significant changes were found in any of the aforementioned parameters. The results showed that improvement of lipid metabolism, especially an increase of HDL cholesterol level and a reduction of MDA-LDL, may inhibit vascular contractility. |
| | |
Authors:
|
Shigemasa Tani; Ken Nagao; Takeo Anazawa; Hirofumi Kawamata; Shingo Furuya; Hiroshi Takahashi; Kiyoshi Iida; Takeshi Fuji; Michiaki Matsumoto; Takamichi Kumabe; Yuichi Sato; Atsushi Hirayama |
Related Documents
:
|
8307387 - 30-minute evaluation of incontinence in the older woman. 23064697 - Comparison of contamination rates between preserved and preservative-free fluoroquinolo... 17720857 - Pre-overloading to extend fatigue life of cast clasps. 15116897 - Is the wear factor in total joint replacements dependent on the nominal contact stress ... 22818547 - Do transfusions cause necrotizing enterocolitis? the complementary role of randomized t... 160737 - Cross-sensitivity within the neomycin group of antibiotics. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of cardiovascular pharmacology Volume: 52 ISSN: 1533-4023 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-07-22 Completed Date: 2008-11-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
|
Languages: eng Pagination: 28-34 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Nihon University Surugadai Hospital, Tokyo, Japan. tanishigem@yahoo.co.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angina Pectoris, Variant
/
drug therapy* Calcium Channel Blockers / therapeutic use* Cholesterol, HDL / blood Cholesterol, LDL / blood Coronary Vasospasm / drug therapy* Dihydropyridines / therapeutic use* Drug Therapy, Combination Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Lipid Metabolism / drug effects Lipoproteins, LDL / blood Male Malondialdehyde / analogs & derivatives, blood Middle Aged Pilot Projects Pravastatin / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Calcium Channel Blockers; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dihydropyridines; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipoproteins, LDL; 0/malondialdehyde-low density lipoprotein, mouse; 105979-17-7/benidipine; 542-78-9/Malondialdehyde; 81093-37-0/Pravastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig.
Next Document: Will warfarin soon be passé? New approaches to stroke prevention in atrial fibrillation.