| Treatment of congenital immune deficiencies with a thymic hormone--thymic humoral factor. | |
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MedLine Citation:
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PMID: 3528049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Five infants with congenital immune defects are presented. Three had various combined immune deficiencies (CID) and two had thymic deficiencies only. As bone marrow or thymus transplantations were not feasible in these patients, we attempted treatment with thymic humoral factor (THF), a thymic hormone, by daily i.m. injections during biweekly courses. In one CID patient, a partial improvement in immune indices and temporary clinical improvement were achieved. In the other two, THF did not arrest the patients' demise. The two patients with thymic dysplasia benefitted repeatedly from THF treatment, as exemplified by the disappearance of wasting, diarrhea and infections and by reconstitution of T cell parameters. Nevertheless, the patients relapsed after prolonged periods without THF administration. We therefore propose the administration of long-term, continuous or intermittent thymic hormone replacement therapy in infants with congenital thymic defects. Early diagnosis and immediate institution of treatment will probably improve prognosis. |
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Authors:
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Z T Handzel; Y Elitsur; S Algrimawi; S Moses; A Keynan; I Amitai; M Pecht; Y Burstein; V Buchner; N Trainin |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Israel journal of medical sciences Volume: 22 ISSN: 0021-2180 ISO Abbreviation: Isr. J. Med. Sci. Publication Date: 1986 May |
Date Detail:
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Created Date: 1986-10-21 Completed Date: 1986-10-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0013105 Medline TA: Isr J Med Sci Country: ISRAEL |
Other Details:
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Languages: eng Pagination: 387-92 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Immunologic Deficiency Syndromes / congenital, diagnosis, drug therapy* Immunologic Techniques Infant Lymphopenia / immunology Male Recurrence Thymus Gland / abnormalities Thymus Hormones / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Thymus Hormones; 63340-72-7/thymic humoral factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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