Document Detail

Treatment of congenital immune deficiencies with a thymic hormone--thymic humoral factor.
MedLine Citation:
PMID:  3528049     Owner:  NLM     Status:  MEDLINE    
Five infants with congenital immune defects are presented. Three had various combined immune deficiencies (CID) and two had thymic deficiencies only. As bone marrow or thymus transplantations were not feasible in these patients, we attempted treatment with thymic humoral factor (THF), a thymic hormone, by daily i.m. injections during biweekly courses. In one CID patient, a partial improvement in immune indices and temporary clinical improvement were achieved. In the other two, THF did not arrest the patients' demise. The two patients with thymic dysplasia benefitted repeatedly from THF treatment, as exemplified by the disappearance of wasting, diarrhea and infections and by reconstitution of T cell parameters. Nevertheless, the patients relapsed after prolonged periods without THF administration. We therefore propose the administration of long-term, continuous or intermittent thymic hormone replacement therapy in infants with congenital thymic defects. Early diagnosis and immediate institution of treatment will probably improve prognosis.
Z T Handzel; Y Elitsur; S Algrimawi; S Moses; A Keynan; I Amitai; M Pecht; Y Burstein; V Buchner; N Trainin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Israel journal of medical sciences     Volume:  22     ISSN:  0021-2180     ISO Abbreviation:  Isr. J. Med. Sci.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-10-21     Completed Date:  1986-10-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0013105     Medline TA:  Isr J Med Sci     Country:  ISRAEL    
Other Details:
Languages:  eng     Pagination:  387-92     Citation Subset:  IM    
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MeSH Terms
Immunologic Deficiency Syndromes / congenital,  diagnosis,  drug therapy*
Immunologic Techniques
Lymphopenia / immunology
Thymus Gland / abnormalities
Thymus Hormones / therapeutic use*
Reg. No./Substance:
0/Thymus Hormones; 63340-72-7/thymic humoral factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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