| Treatment of condyloma acuminatum with three different interferons administered intralesionally. A double-blind, placebo-controlled trial. | |
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MedLine Citation:
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PMID: 3358568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVE: To determine the efficacy and toxicity of intralesionally administered interferons in the treatment of condyloma acuminatum. DESIGN: Randomized, double-blind, and placebo-controlled study. SETTING: Outpatient clinics at university medical centers. PATIENTS: Seventy-nine patients with biopsy-proved condyloma acuminatum that was refractory to conventional therapy were enrolled in the study. INTERVENTIONS: Alpha-2b, alpha-nl-, and beta-interferons were used. One wart on each patients was injected three times per week for 4 weeks with either 1 x 10(6) units of interferon or placebo. MEASUREMENTS AND MAIN RESULTS: Forty-seven percent of warts injected with interferon resolved completely, compared with 22% of placebo-injected warts (P = 0.009). In addition, more recipients of interferon had a complete resolution of uninjected lesions. No differences in rates of response were noted among the different interferon groups. Approximately one third of interferon-injected warts recurred, compared with none of four placebo-injected warts. Intralesionally administered interferon was nontoxic and well tolerated, although transient pain on injection was observed frequently. CONCLUSIONS: Intralesional administration of each of these three interferons appears to be useful in treating condyloma acuminatum. However, the frequent recurrence of disease and the failure of many lesions to resolve indicate that different regimens, such as longer courses of therapy or different routes of administration, should be evaluated to maximize beneficial effects of interferon for treating this common sexually transmitted disease. |
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Authors:
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R C Reichman; D Oakes; W Bonnez; C Greisberger; S Tyring; L Miller; R Whitley; H Carveth; M Weidner; G Krueger |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of internal medicine Volume: 108 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1988 May |
Date Detail:
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Created Date: 1988-05-16 Completed Date: 1988-05-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 675-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Rochester School of Medicine and Dentistry, New York. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anus Neoplasms / therapy Condylomata Acuminata / pathology, therapy* Double-Blind Method Female Genital Neoplasms, Female / therapy Genital Neoplasms, Male / therapy Humans Injections Interferon Type I / administration & dosage*, adverse effects, blood Male Neoplasm Recurrence, Local Random Allocation |
| Grant Support | |
ID/Acronym/Agency:
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N01-AI-32510/AI/NIAID NIH HHS; RR032/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interferon Type I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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