| Treatment and complications of thalassemia major in Guangxi, Southern China. | |
| | |
MedLine Citation:
|
PMID: 21394896 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: β-Thalassemia is extremely prevalent in Guangxi province, Southern China. However, little is known about the treatment and complications of patients with thalassemia major (TM) in Guangxi. The first thalassemia center in China was opened in Guangxi in 2003. Since that time, more than 400 patients have been enrolled. PROCEDURE: From December 2009 to February 2010, data was collected from TM patients visiting the thalassemia center including the circumstances of diagnosis, biological and clinical data, markers of iron overload and treatment. RESULTS: Data on 231 patients (median age, 5 years; range, 5 months to 21 years) were recorded. Only 44.6% of patients maintained their hemoglobin levels >9.0 g/dl. In 186 patients with ferritin levels >1,000 ng/ml, an iron chelator was used regularly in 44.6%, irregularly in 26.9%, and was not used in 28.5%. The mean serum ferritin level was 3,143 ng/ml and levels increased with age. Height and weight retardation were found in 48.3% and 11.1% patients, respectively. Compared to patients treated outside of the center, patients completing treatment in the thalassemia center had a higher hemoglobin level before transfusion, higher height and weight SD score, and less splenomegaly, but a similar ratio of regular or irregular iron chelation. Six (18.2%) of 33 patients >10 years of age (14.3 ± 2.8 years; range, 11-19 years) were diagnosed as hypothyroid. CONCLUSIONS: Although survival status of patients with TM in Guangxi has improved since the opening of the thalassemia center, TM complications remain high and with an early onset. Pediatr Blood Cancer © 2011 Wiley-Liss, Inc. |
| | |
Authors:
|
Xiao-Lin Yin; Zhi-Kui Wu; Yuan-Yuan He; Tian-Hong Zhou; Ya-Li Zhou; Xin Hua Zhang |
Related Documents
:
|
9509106 - Acute food bolus impaction: aetiology and management. 10468756 - Does the position of the patient affect the presence and/or degree of reflux in an ilea... 11103536 - Value of pharyngography in patients without suprasternal symptoms. 7151706 - Metoclopramide in the treatment of an infant with gastroesophageal hypomotility. 11307696 - His mother-tongue: from stuttering to separation, a case history. 2860446 - Peripheral neuropathy in patients treated with almitrine dimesylate. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-10 |
Journal Detail:
|
Title: Pediatric blood & cancer Volume: - ISSN: 1545-5017 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
|
Department of Hematology, 303rd Hospital of People's Liberation Army, Nanning, Guangxi, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: No advantage of a rotational continuation phase in acute lymphoblastic leukemia in childhood treated...
Next Document: Biological behavior of pre-osteoblasts on natural hydroxyapatite: A study of signaling molecules fro...