Document Detail

Treatment of coccidioidomycosis with miconazole.
MedLine Citation:
PMID:  7365975     Owner:  NLM     Status:  MEDLINE    
Miconazole was injected intravenously in six patients with coccidioidomycosis. Two patients received 101 and 185 g, respectively, without clinical response and with persistence of positive cultures for Coccidioides immitis. In one patient, symptoms were suppressed when amphotericin B was given with miconazole, but new lesions developed with miconazole alone (total dose, 963 g). Three patients received smaller doses: 30.6 g before death from an unrelated complication; 17 and 22.3 g before development of severe allergic reactions. Because of the high rate of initial failures and relapses, miconazole is not recommended as primary therapy for coccidioidomycosis.
P D Hoeprich; R M Lawrence; E Goldstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JAMA     Volume:  243     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1923-6     Citation Subset:  AIM; IM    
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MeSH Terms
Amphotericin B / administration & dosage
Coccidioidomycosis / drug therapy*
Drug Evaluation
Drug Therapy, Combination
Imidazoles / therapeutic use*
Injections, Intravenous
Miconazole / administration & dosage,  adverse effects,  therapeutic use*
Middle Aged
Reg. No./Substance:
0/Imidazoles; 7NNO0D7S5M/Miconazole; 7XU7A7DROE/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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