Document Detail

Treatment of chronical myocardial ischemia by adenovirus-mediated hepatocyte growth factor gene transfer in minipigs.
MedLine Citation:
PMID:  18488174     Owner:  NLM     Status:  MEDLINE    
Growth factor gene transfer-induced therapeutic angiogenesis has become a novel approach for the treatment of myocardial ischemia. In order to provide a basis for the clinical application of an adenovirus with hepatocyte growth factor gene (Ad-HGF) in the treatment of myocardial ischemia, we established a minipig model of chronically ischemic myocardium in which an Ameroid constrictor was placed around the left circumflex branch of the coronary artery (LCX). A total of 18 minipigs were randomly divided into 3 groups: a surgery control group, a model group and an Ad-HGF treatment group implanted with Ameroid constrictor. Ad-HGF or the control agent was injected directly into the ischemic myocardium, and an improvement in heart function and blood supply were evaluated. The results showed that myocardial perfusion remarkably improved in the Ad-HGF group compared with that in both the control and model groups. Four weeks after the treatment, the density of newly formed blood vessels was higher and the number of collateral blood vessels was greater in the Ad-HGF group than in the model group. The area of myocardial ischemia reduced evidently and the left ventricular ejection fraction improved significantly in the Ad-HGF group. These results suggest that HGF gene therapy may become a novel approach in the treatment of chronically ischemic myocardium.
Biao Yuan; YouRong Zhang; Zhong Zhao; DanLi Wu; LiZhen Yuan; Bin Wu; LiSheng Wang; Jun Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-17
Journal Detail:
Title:  Science in China. Series C, Life sciences / Chinese Academy of Sciences     Volume:  51     ISSN:  1006-9305     ISO Abbreviation:  Sci. China, C, Life Sci.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9611809     Medline TA:  Sci China C Life Sci     Country:  China    
Other Details:
Languages:  eng     Pagination:  537-43     Citation Subset:  IM    
The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
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MeSH Terms
Adenoviridae / genetics*
Gene Therapy*
Genetic Vectors*
Hepatocyte Growth Factor / genetics*
Myocardial Ischemia / radionuclide imaging,  therapy*,  ultrasonography
Swine, Miniature
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
67256-21-7/Hepatocyte Growth Factor

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