| Treatment of chronic type B hepatitis in Southeast Asia. | |
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MedLine Citation:
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PMID: 3044079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In Southeast Asia, 15 to 20 percent of the population are hepatitis B surface antigen carriers. The majority of these carriers have chronic hepatitis and would progress to cirrhosis or hepatocellular carcinoma at an annual incidence of 2 percent and 1 percent, respectively. Previous studies from Southeast Asia suggested that immunosuppressive therapy could be harmful, or at best of no value, and antiviral treatment with vidarabine, picibanil, or even interferon was also unsatisfactory. Currently, a randomized controlled trial of human lymphoblastoid interferon, with or without prednisolone pretreatment, versus placebo in patients with hepatitis B core antigen in the liver and hepatitis B e antigen in the serum is being conducted. Forty-five patients (29 receiving interferon, 16 receiving placebo) have been entered in the trial for at least two months. Actuarial analysis shows that the response to interferon therapy was better than that to placebo. Although flu-like symptoms, hair loss, and body weight loss were seen, no side effect requiring specific treatment has been encountered. These preliminary results suggest that human lymphoblastoid interferon is effective and safe in Oriental patients. |
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Authors:
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Y F Liaw; S M Lin; I S Sheen; T J Chen; C M Chu |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of medicine Volume: 85 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-09-22 Completed Date: 1988-09-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 147-9 Citation Subset: AIM; IM |
Affiliation:
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Liver Unit, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Asia, Southeastern Clinical Trials as Topic Female Hepatitis B / therapy* Hepatitis, Chronic / therapy* Humans Immunosuppression Interferon Type I / therapeutic use* Male Placebos Prednisolone / therapeutic use Random Allocation Taiwan |
| Chemical | |
Reg. No./Substance:
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0/Interferon Type I; 0/Placebos; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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