| Treatment for chronic prostatitis/chronic pelvic pain syndrome: levofloxacin, doxazosin and their combination. | |
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MedLine Citation:
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PMID: 18362485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: We performed a prospective, randomized study to examine the efficacies of levofloxacin and doxazosin alone and as a combination therapy in patients with National Institutes of Health (NIH) category III chronic prostatitis/chronic pelvic pain syndrome. PATIENTS AND METHODS: Men with a NIH diagnosis of category III chronic prostatitis/chronic pelvic pain syndrome and who had experienced pelvic pain for more than 3 months during the last 6 months were enrolled. All patients underwent treatment for 6 weeks. The patients were assessed at baseline and after 2 and 6 weeks by using the NIH Chronic Prostatitis Symptom Index. Eighty-one men (average age 40.1 years) were randomized to either the levofloxacin group (n = 26), the doxazosin group (n = 26), or the combination group (n = 29). RESULTS: The average baseline NIH Chronic Prostatitis Symptom Index total scores were 22.6, 22.4, and 24.1, respectively. At 6 weeks, the total scores were 11.2 (response rate 50.3%), 17.7 (response rate 21.1%), and 13.1 (response rate 45.6%), respectively. The levofloxacin group showed a higher response rate than the doxazosin group, not at 2 weeks but at 6 weeks (p < 0.001). CONCLUSIONS: For a 6-week short-term treatment levofloxacin is more effective than doxazosin for chronic prostatitis/chronic pelvic pain syndrome. In addition, levofloxacin monotherapy was also more effective when compared with the combination therapy. |
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Authors:
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Chang Wook Jeong; Dae Jung Lim; Hwancheol Son; Sang Eun Lee; Hyeon Jeong |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2008-03-19 |
Journal Detail:
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Title: Urologia internationalis Volume: 80 ISSN: 1423-0399 ISO Abbreviation: Urol. Int. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-03-25 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417373 Medline TA: Urol Int Country: Switzerland |
Other Details:
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Languages: eng Pagination: 157-61 Citation Subset: IM |
Affiliation:
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Department of Urology, Seoul National University Hospital, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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therapeutic use* Adult Anti-Bacterial Agents / therapeutic use* Doxazosin / therapeutic use* Drug Therapy, Combination Humans Male Middle Aged Ofloxacin / therapeutic use* Prospective Studies Prostatitis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Anti-Bacterial Agents; 74191-85-8/Doxazosin; 82419-36-1/Ofloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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