Document Detail


Treatment for chronic prostatitis/chronic pelvic pain syndrome: levofloxacin, doxazosin and their combination.
MedLine Citation:
PMID:  18362485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: We performed a prospective, randomized study to examine the efficacies of levofloxacin and doxazosin alone and as a combination therapy in patients with National Institutes of Health (NIH) category III chronic prostatitis/chronic pelvic pain syndrome. PATIENTS AND METHODS: Men with a NIH diagnosis of category III chronic prostatitis/chronic pelvic pain syndrome and who had experienced pelvic pain for more than 3 months during the last 6 months were enrolled. All patients underwent treatment for 6 weeks. The patients were assessed at baseline and after 2 and 6 weeks by using the NIH Chronic Prostatitis Symptom Index. Eighty-one men (average age 40.1 years) were randomized to either the levofloxacin group (n = 26), the doxazosin group (n = 26), or the combination group (n = 29). RESULTS: The average baseline NIH Chronic Prostatitis Symptom Index total scores were 22.6, 22.4, and 24.1, respectively. At 6 weeks, the total scores were 11.2 (response rate 50.3%), 17.7 (response rate 21.1%), and 13.1 (response rate 45.6%), respectively. The levofloxacin group showed a higher response rate than the doxazosin group, not at 2 weeks but at 6 weeks (p < 0.001). CONCLUSIONS: For a 6-week short-term treatment levofloxacin is more effective than doxazosin for chronic prostatitis/chronic pelvic pain syndrome. In addition, levofloxacin monotherapy was also more effective when compared with the combination therapy.
Authors:
Chang Wook Jeong; Dae Jung Lim; Hwancheol Son; Sang Eun Lee; Hyeon Jeong
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-03-19
Journal Detail:
Title:  Urologia internationalis     Volume:  80     ISSN:  1423-0399     ISO Abbreviation:  Urol. Int.     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-25     Completed Date:  2008-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417373     Medline TA:  Urol Int     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  157-61     Citation Subset:  IM    
Affiliation:
Department of Urology, Seoul National University Hospital, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / therapeutic use*
Adult
Anti-Bacterial Agents / therapeutic use*
Doxazosin / therapeutic use*
Drug Therapy, Combination
Humans
Male
Middle Aged
Ofloxacin / therapeutic use*
Prospective Studies
Prostatitis / drug therapy*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Anti-Bacterial Agents; 74191-85-8/Doxazosin; 82419-36-1/Ofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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