| Treatment of chronic myeloid leukemia when imatinib fails. | |
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MedLine Citation:
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PMID: 21226637 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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INTRODUCTION: Imatinib failure represents a major clinical challenge in the management of chronic myeloid leukemia. AREAS COVERED: Definition of failure, its causes, the various approaches to the treatment of imatinib failure such as imatinib dose escalation, second-generation tyrosine kinase inhibitors and stem cell transplantation, and monitoring of residual disease are covered in this review. Selected investigational agents and the management of blast crisis are also reviewed. After reading the review the reader will understand how to manage imatinib failure. EXPERT OPINION: Imatinib failure can be managed in most cases by a careful appraisal of its causes and a rational selection of treatment options. |
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Authors:
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Rüdiger Hehlmann; Susanne Jung-Munkwitz; Susanne Saussele |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Expert opinion on pharmacotherapy Volume: 12 ISSN: 1744-7666 ISO Abbreviation: Expert Opin Pharmacother Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897346 Medline TA: Expert Opin Pharmacother Country: England |
Other Details:
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Languages: eng Pagination: 269-83 Citation Subset: IM |
Affiliation:
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III. Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Pettenkoferstrasse 22, Mannheim, Germany. ruediger.hehlmann@medma.uni-heidelberg.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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