Document Detail


Treatment of chronic inflammatory diseases with implantable medical devices.
MedLine Citation:
PMID:  21972327     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Implantable medical devices are finding increasing use in the treatment of diseases traditionally targeted with drugs. It is well established that the cholinergic anti-inflammatory pathway serves as a physiological regulator of inflammatory responses, but stimulation of this pathway therapeutically by electrical stimulation of the vagus nerve can also diminish excessive or dysregulated states of inflammation. Recent data from a wide variety of animal models, as well as evidence of reduced vagal tone in rheumatoid arthritis and other inflammatory diseases, support the rationale for, and feasibility of, developing implantable vagal nerve stimulation devices to treat chronic inflammation in humans.
Authors:
Ralph J Zitnik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cleveland Clinic journal of medicine     Volume:  78 Suppl 1     ISSN:  1939-2869     ISO Abbreviation:  Cleve Clin J Med     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-10-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703441     Medline TA:  Cleve Clin J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S30-4     Citation Subset:  IM    
Affiliation:
SetPoint Medical Corporation, 222 Berkeley Street, 20th Floor, Boston, MA 02116; rzitnik@setpointmedical.com.
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