Document Detail


Treatment of chronic hepatitis delta virus with peg-interferon and factors that predict sustained viral response.
MedLine Citation:
PMID:  23155322     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To observe the efficacy of peg-interferon in the treatment of hepatitis delta virus (HDV) and to identify the factors that would be predictive of the sustained viral response (SVR).
METHODS: This prospective study was conducted in Medical Unit IV of the Liaquat University of Medical and Health Sciences Hospital Jamshoro from June 2008 to September 2011. This study cohort included all patients of either sex who presented during this time with hepatitis B surface antigen positivity, hepatitis B virus DNA > 20,000 IU/mL, serum glutamic pyruvic transaminase (SGPT) > 2(upper limit of normal), HDV-RNA positivity with fibrosis stage ≥ 2. Informed consent was obtained from each of these individuals. Patients were diagnosed with hepatitis D on the basis of detectable viral antibodies and the presence of HDV-RNA in their serum. A liver biopsy was performed in all cases and fibrosis staging was performed in accordance with the METAVIR scoring system. All eligible patients were administered peg-interferon at a weekly dosage of 1.5 μg/kg body weight for 48 wk. HDV-RNA was assayed at the end of this treatment period and again at 24 wk later. A biochemical response was determined by a normalization of SGPT at the end of the treatment or during follow up. The end of treatment response was defined by a HDV-RNA negative status. A sustained virological response was defined by undetectable serum HDV-RNA at six months after the end of treatment.
RESULTS: Among the 277 patients enrolled in our present study, 238 completed a course of peg-interferon therapy of which 180 (75.6%) were male and 58 (24.4%) female. Biochemical responses were achieved in 122/238 (51.3%) patients. End of treatment responses were achieved in 71/238 (29.8%) cases. A SVR was achieved in 70 of these patients (29.4%). A strong association was found between the SVR and the end of treatment responses (P = 0.001), biochemical responses (P = 0.001) and the degree of fibrosis (P = 0.002).
CONCLUSION: Peg-interferon therapy can induce remission in nearly one third of patients harboring HDV.
Authors:
Shaikh Samiullah; Devrajani Bikharam; Nasreen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  18     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-11-12     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  5793-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiviral Agents / therapeutic use*
Biopsy
Female
Hepatitis Antibodies / blood
Hepatitis D, Chronic / blood,  complications,  diagnosis,  drug therapy*
Hepatitis Delta Virus / drug effects*,  genetics,  immunology
Humans
Interferons / therapeutic use*
Liver Cirrhosis / diagnosis,  drug therapy,  virology
Male
Pakistan
Polyethylene Glycols / therapeutic use*
Prospective Studies
RNA, Viral / blood
Remission Induction
Time Factors
Treatment Outcome
Viral Load
Young Adult
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Hepatitis Antibodies; 0/Polyethylene Glycols; 0/RNA, Viral; 9008-11-1/Interferons
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