| Treatment of chronic hepatitis B in 2002. | |
| | |
MedLine Citation:
|
PMID: 12839213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Viral hepatitis B is a serious health problem, above all in the world's developing countries. It is estimated that two billion people will be infected with the hepatitis B virus in the course of their lives and between 350 and 400 million people are chronically infected at present. The aims of the treatment of chronic hepatitis B are sustained suppression of viral replication and remission of liver disease. For the treatment of chronic hepatitis B two drugs have been licensed worldwide: alpha-interferon and lamivudine. In chronic hepatitis B therapy there are new developments in antiviral, such as nucleoside analogues--entecavir, emtricitabine, clevudine, beta-L-nucleosides. Studies comparing pegylated interferon with lamivudine and with the combination of lamivudine and pegylated interferon are in progress. Several innovative antiviral approaches have been evaluated in vitro, and in animal models of hepadnavirus infections. These approaches are including antisense oligonucleotides, ribozymes, inhibitors blocking virus entry into hepatocytes, and decoy virus or dominant negative mutants. |
| | |
Authors:
|
P Husa; L Husova |
Related Documents
:
|
15648063 - Clinical and virological characteristics of lamivudine resistance in chronic hepatitis ... 15919623 - Management of patients co-infected with hepatitis b virus and hiv. 16182583 - Evaluation of nuclisens-ampliscreen methodology to detect subtypes g of hiv-1 and 4c/4d... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Bratislavské lekárske listy Volume: 104 ISSN: 0006-9248 ISO Abbreviation: Bratisl Lek Listy Publication Date: 2003 |
Date Detail:
|
Created Date: 2003-07-03 Completed Date: 2003-07-22 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0065324 Medline TA: Bratisl Lek Listy Country: Slovakia |
Other Details:
|
Languages: eng Pagination: 59-63 Citation Subset: IM |
Affiliation:
|
Department of Infectious Diseases, University Hospital, Masaryk University, Brno, Czech Republic. phusa@med.muni.cz |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antiviral Agents
/
therapeutic use Hepatitis B, Chronic / drug therapy* Humans |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Selective posterior rhizotomy in the treatment of cerebral palsy, first experience in Czech Republic...
Next Document: Free radical disease prevention and nutrition.