Document Detail


Treatment of chronic hepatitis B in 2002.
MedLine Citation:
PMID:  12839213     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Viral hepatitis B is a serious health problem, above all in the world's developing countries. It is estimated that two billion people will be infected with the hepatitis B virus in the course of their lives and between 350 and 400 million people are chronically infected at present. The aims of the treatment of chronic hepatitis B are sustained suppression of viral replication and remission of liver disease. For the treatment of chronic hepatitis B two drugs have been licensed worldwide: alpha-interferon and lamivudine. In chronic hepatitis B therapy there are new developments in antiviral, such as nucleoside analogues--entecavir, emtricitabine, clevudine, beta-L-nucleosides. Studies comparing pegylated interferon with lamivudine and with the combination of lamivudine and pegylated interferon are in progress. Several innovative antiviral approaches have been evaluated in vitro, and in animal models of hepadnavirus infections. These approaches are including antisense oligonucleotides, ribozymes, inhibitors blocking virus entry into hepatocytes, and decoy virus or dominant negative mutants.
Authors:
P Husa; L Husova
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bratislavské lekárske listy     Volume:  104     ISSN:  0006-9248     ISO Abbreviation:  Bratisl Lek Listy     Publication Date:  2003  
Date Detail:
Created Date:  2003-07-03     Completed Date:  2003-07-22     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0065324     Medline TA:  Bratisl Lek Listy     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  59-63     Citation Subset:  IM    
Affiliation:
Department of Infectious Diseases, University Hospital, Masaryk University, Brno, Czech Republic. phusa@med.muni.cz
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents / therapeutic use
Hepatitis B, Chronic / drug therapy*
Humans
Chemical
Reg. No./Substance:
0/Antiviral Agents

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