Document Detail


Treatment of chronic dermatophytosis and chronic oral candidosis with itraconazole.
MedLine Citation:
PMID:  3027834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Itraconazole was evaluated in patients with forms of superficial fungal infection that were previously unresponsive to treatment. Two groups of patients were treated, those with chronic dermatophytosis caused by Trichophyton rubrum affecting the body (10) or palm (five) and those with chronic oral candidosis (eight). All of the patients with dermatophytosis achieved complete remission in a mean period of 9.1 weeks, with three subsequent relapses. Seven patients with oral candidosis had originally presented with chronic mucocutaneous candidosis; recurrent or persistent oral candidosis had developed after initially successful treatment with ketoconazole. All of the patients with chronic oral candidal infections responded to itraconazole after a mean treatment period of 5.4 weeks, with two subsequent relapses. These results indicate that itraconazole is effective in treating these recalcitrant superficial mycoses and should be assessed in a larger unselected group of patients and compared with alternative drugs.
Authors:
R J Hay; Y M Clayton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reviews of infectious diseases     Volume:  9 Suppl 1     ISSN:  0162-0886     ISO Abbreviation:  Rev. Infect. Dis.     Publication Date:    1987 Jan-Feb
Date Detail:
Created Date:  1987-03-18     Completed Date:  1987-03-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905878     Medline TA:  Rev Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S114-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antifungal Agents / therapeutic use*
Candidiasis, Oral / drug therapy*
Chronic Disease
Female
Humans
Itraconazole
Ketoconazole / analogs & derivatives*,  therapeutic use
Male
Middle Aged
Onychomycosis / drug therapy
Tinea / drug therapy*
Chemical
Reg. No./Substance:
0/Antifungal Agents; 65277-42-1/Ketoconazole; 84625-61-6/Itraconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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