Document Detail

Treatment of chronic atrial fibrillation in the elderly, assessed by ambulatory electrocardiographic monitoring.
MedLine Citation:
PMID:  7430528     Owner:  NLM     Status:  MEDLINE    
This study concerns 8 elderly patients with age-related chronic atrial fibrillation that required control of the ventricular response. The effects of oral administration of placebo, pindolol, verapamil, digoxin and digoxin + pindolol were assessed (each for a week) during three daily activity and sleep sessions, over a six-week period. Cardiac rhythm was monitored by taped electrocardiograms. Either digoxin or pindolol was effective, but digoxin was the best tolerated of all the drugs. A combination of pindolol and digoxin reduced the maximum ventricular rate without further depression of the minimum ventricular rate. Digoxin seems to be well tolerated in the control of atrial fibrillation in the elderly, and beta blockade may be a useful therapeutic adjunct.
R Wang; J Camm; D Ward; H Washington; A Martin
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  28     ISSN:  0002-8614     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  529-34     Citation Subset:  IM    
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MeSH Terms
Atrial Fibrillation / diagnosis,  drug therapy*
Digoxin / administration & dosage*
Drug Tolerance
Electrocardiography / methods*
Evaluation Studies as Topic
Heart Rate / drug effects
Middle Aged
Pindolol / administration & dosage*
Verapamil / administration & dosage*
Reg. No./Substance:
0/Placebos; 13523-86-9/Pindolol; 20830-75-5/Digoxin; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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