Document Detail

Treatment of childhood kaposiform hemangioendothelioma with sirolimus.
MedLine Citation:
PMID:  20730884     Owner:  NLM     Status:  MEDLINE    
Sirolimus (Rapamune), a mammalian target of Rapamycin (mTOR) inhibitor, which has been used extensively in children following solid organ transplantation, has been demonstrated to have anti-angiogenic activity in pre-clinical models. Limited experience suggests that it may have application to the treatment of vascular lesions. We describe our experience with a 1-year-old female with a kaposiform hemangioendothelioma and Kasabach-Merritt phenomenon who had rapid and dramatic response to sirolimus (0.1 mg/kg/day). This case provides further rationale for clinical trials of sirolimus in the treatment of vascular lesions.
Julie Blatt; Joseph Stavas; Billie Moats-Staats; John Woosley; Dean S Morrell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  55     ISSN:  1545-5017     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-28     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1396-8     Citation Subset:  IM    
Division of Pediatric Hematology Oncology, Vascular Lesions Clinic, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
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MeSH Terms
Angiogenesis Inhibitors / therapeutic use*
Antibiotics, Antineoplastic / therapeutic use*
Hemangioendothelioma / blood,  drug therapy*,  pathology
Platelet Count
Sirolimus / therapeutic use*
Skin Neoplasms / blood,  drug therapy*,  pathology
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antibiotics, Antineoplastic; 53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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