| Treatment of childhood brucellosis: results of a prospective trial on 113 children. | |
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MedLine Citation:
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PMID: 8327297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of childhood brucellosis is controversial and is currently dependent on inclusion of aminoglycoside antibiotics which are both costly and potentially toxic. Hence an alternate mode of therapy preferably dependent exclusively on oral agents is desirable because this decreases medical cost. In this study we prospectively treated 113 children with a combination of two oral agents, trimethoprim-sulfamethoxazole (10 to 12 mg/kg trimethoprim, 50 to 60 mg/kg sulfamethoxazole and rifampin 15 to 20 mg/kg in two divided doses for 6 weeks. The treatment was well-tolerated and all patients responded by defervescence of fever and resolution of all symptoms within 1 to 3 weeks. Relapse after 6 months occurred in four children all of whom responded to repeat therapy by the same agents. We conclude that the combination of trimethoprim-sulfamethoxazole and rifampin is both cost-effective and safe for the treatment of childhood brucellosis. |
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Authors:
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N A Khuri-Bulos; A H Daoud; S M Azab |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: The Pediatric infectious disease journal Volume: 12 ISSN: 0891-3668 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-08-12 Completed Date: 1993-08-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 377-81 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Jordan University Hospital, Amman. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adolescent Agglutination Tests Alanine Transaminase / blood Aspartate Aminotransferases / blood Blood Cell Count Brucellosis / diagnosis, drug therapy* Child Child, Preschool Drug Therapy, Combination Female Follow-Up Studies Humans Male Prospective Studies Recurrence Rifampin / administration & dosage, therapeutic use* Seasons Trimethoprim-Sulfamethoxazole Combination / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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13292-46-1/Rifampin; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
| Comments/Corrections | |
Comment In:
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Pediatr Infect Dis J. 1994 Apr;13(4):335-6
[PMID:
8036060
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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