Document Detail

Treatment of childhood acute lymphoblastic leukemia with protocol TCL821: a report of Taiwan Children's Cancer Study Group.
MedLine Citation:
PMID:  2666568     Owner:  NLM     Status:  MEDLINE    
Of 110 previously untreated patients who had entered the study of protocol TCL821, 96 were evaluable. The patients were divided into a standard risk group (Group I) and a high risk group (Group II) depending on their age and leukocyte count at the time of diagnosis. Treatment consisted of a 5-week induction therapy course with prednisolone (PRED), vincristine (VCR) and adriamycin (ADM) followed by central nervous system (CNS) prophylaxis. Maintenance therapy consisted of 6-mercaptopurine (6-MP) plus methotrexate (MTX) for 3 years and 6-MP alone for another 2 years, reinforced with dexamethasone, VCR and ADM or cytosine-arabinoside (Ara-C) or cyclophosphamide (CTX) every 16 weeks for Group I and 8 weeks for Group II for 3 years. Immunologic typing was done in 74 cases which revealed 60.9% of the common acute lymphoblastic leukemia (ALL) type, 14.9% null cell type, 4.0% undifferentiated type, 4.0% Pre-B cell type, 4.0% B cell type, 10.8% Pre-T cell type and 1.4% T cell type. In Group I the complete remission rate (CR) was 100% and the continuous complete remission rate (CCR) was 72.2% with a follow-up duration of 40-73 months. In Group II, both CR and CCR were 92.9% and 45.8% respectively. The incidence of patients with Pre-T cell type was higher in this study than in most other reports, and these patients responded favorably to treatment.
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association     Volume:  88     ISSN:  0371-7682     ISO Abbreviation:  Taiwan Yi Xue Hui Za Zhi     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0413761     Medline TA:  Taiwan Yi Xue Hui Za Zhi     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  48-56     Citation Subset:  IM    
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MeSH Terms
6-Mercaptopurine / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Asparaginase / administration & dosage
Child, Preschool
Combined Modality Therapy
Cytarabine / administration & dosage
Dexamethasone / administration & dosage
Doxorubicin / administration & dosage
Evaluation Studies as Topic
Follow-Up Studies
Hydrocortisone / administration & dosage
Methotrexate / administration & dosage
Multicenter Studies as Topic
Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
Prednisolone / administration & dosage
Remission Induction
Vincristine / administration & dosage
Reg. No./Substance:
147-94-4/Cytarabine; 23214-92-8/Doxorubicin; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 50-24-8/Prednisolone; 50-44-2/6-Mercaptopurine; 57-22-7/Vincristine; 59-05-2/Methotrexate; EC

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