Document Detail


Treatment of chemotherapy-induced neutropenia in children with subcutaneously administered recombinant human granulocyte colony-stimulating factor.
MedLine Citation:
PMID:  1381941     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifty-six children with various malignancies were treated subcutaneously with recombinant human granulocyte colony-stimulating factor (rhG-CSF, KRN 8601) for neutropenia induced by cancer chemotherapy. Patients received the first chemotherapy without rhG-CSF (control course). In the second course, rhG-CSF was given once daily, starting 3 days after completion of identical chemotherapy (day 3) and continuing until day 12. At day 12, the white blood counts and neutrophil counts were found to be 6.8 and 30 times higher in the rhG-CSF course than in the control course (P = .0001) Nadirs of white blood counts and neutrophils were significantly elevated in the rhG-CSF course (P = .003 and .0001, respectively). rhG-CSF administration shortened the neutropenic period in the majority of patients. Children tolerated the rhG-CSF administration well and we have hereby confirmed that rhG-CSF administration is useful for proceeding with chemotherapy in children with cancer.
Authors:
J Okamura; M Yokoyama; I Tsukimoto; A Komiyama; M Sakurai; S Imashuku; S Miyazaki; K Ueda; Y Hanawa; F Takaku
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Pediatric hematology and oncology     Volume:  9     ISSN:  0888-0018     ISO Abbreviation:  Pediatr Hematol Oncol     Publication Date:    1992 Jul-Sep
Date Detail:
Created Date:  1992-10-22     Completed Date:  1992-10-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8700164     Medline TA:  Pediatr Hematol Oncol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  199-207     Citation Subset:  IM    
Affiliation:
Section of Pediatrics, National Kyushu Cancer Center, Fukuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antineoplastic Agents / adverse effects*
Bone Marrow / drug effects
Child
Child, Preschool
Female
Granulocyte Colony-Stimulating Factor / administration & dosage*,  adverse effects,  pharmacokinetics
Humans
Infant
Infant, Newborn
Injections, Subcutaneous
Male
Neutropenia / blood,  chemically induced,  drug therapy*
Recombinant Proteins / administration & dosage,  adverse effects,  pharmacokinetics
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Recombinant Proteins; 143011-72-7/Granulocyte Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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