Document Detail

Treatment of bone disease with dihydrotachysterol in patients undergoing long-term hemodialysis.
MedLine Citation:
PMID:  907948     Owner:  NLM     Status:  MEDLINE    
Nine of 24 patients undergoing long-term hemodialysis were found to have evidence of moderate to severe bone disease. Two had bone pain and muscle weakness and two had pseudofractures. Eight of the nine were treated with dihydrotachysterol (DHT), 0.25 to 0.375 mg/d initially, but four required doses between 0.5 and 1.0 mg/d. Ther serum alkaline phosphatase value decreased in all patients and returned to normal in six. The bone pain and muscle weakness resolved and the pseudofractures healed. Bone biopsies in six patients before and after initiation of treatment with DHT showed that the osteoid area decreased significantly from 29.6 +/- 22.8% (mean +/- standard deviation) to 11.5 +/- 7.5% (P less than 0.025) and the resorptive surface decreased in all patients. DHT, in doses of up to 1.0 mg/d, is effective in treating both the osteitis fibrosa and the osteomalacic components of bone disease in patients undergoing hemodialysis.
P E Cordy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian Medical Association journal     Volume:  117     ISSN:  0008-4409     ISO Abbreviation:  Can Med Assoc J     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1977-11-30     Completed Date:  1977-11-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0414110     Medline TA:  Can Med Assoc J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  766-8     Citation Subset:  AIM; IM    
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MeSH Terms
Bone and Bones / pathology,  radiography
Calcium / blood
Dihydrotachysterol / pharmacology,  therapeutic use*
Osteomalacia / drug therapy
Renal Dialysis*
Renal Osteodystrophy / drug therapy*,  pathology,  radiography
Reg. No./Substance:
67-96-9/Dihydrotachysterol; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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