| Treatment of bacterial vaginosis with oral or vaginal ornidazole, secnidazole and metronidazole. | |
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MedLine Citation:
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PMID: 9722127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the clinical efficacy and tolerance of oral or vaginal ornidazole, secnidazole and metronidazole or their combinations for treatment of bacterial vaginosis. METHOD: In an open, randomized, prospective study, 152 patients with bacterial vaginosis according to Amsel's criteria were included into the study. The patients were divided into eight groups: (1) oral ornidazole 2 x 500 mg/day for 5 days; (2) vaginal ornidazole 500 mg/day for 5 days; (3) oral and vaginal ornidazole for 5 days; (4) oral secnidazole 2 g in a single dose; (5) oral secnidazole 2 g in a single dose and vaginal ornidazole 500 mg/day for 5 days; (6) oral secnidazole 2 g in a single dose and vaginal metronidazole 2 x 500 mg/day for 7 days; (7) oral ornidazole 2 x 500 mg/day for 5 days and vaginal metronidazole 2 x 500 mg/day for 7 days; and (8) vaginal metronidazole 2 x 500 mg/day for 7 days. None of the partners received any treatment. RESULT: We found a 100% cure rate in both oral and vaginal ornidazole and oral secnidazole-vaginal metronidazole groups. CONCLUSION: Vaginal treatments including ornidazole and metronidazole are not as effective as both oral and vaginal drug combinations. |
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Authors:
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F Saraçoğlu; K Göl; I Sahin; B Türkkani; C Atalay; C Oztopçu |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 62 ISSN: 0020-7292 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-11-06 Completed Date: 1998-11-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: IRELAND |
Other Details:
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Languages: eng Pagination: 59-61 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Numune Hospital, Ankara, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intravaginal Administration, Oral Anti-Infective Agents / administration & dosage* Drug Therapy, Combination Female Humans Metronidazole / administration & dosage, analogs & derivatives*, therapeutic use Ornidazole / administration & dosage* Recurrence Treatment Outcome Vaginosis, Bacterial / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 16773-42-5/Ornidazole; 3366-95-8/secnidazole; 443-48-1/Metronidazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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