Document Detail


Treatment of bacterial vaginosis with oral or vaginal ornidazole, secnidazole and metronidazole.
MedLine Citation:
PMID:  9722127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the clinical efficacy and tolerance of oral or vaginal ornidazole, secnidazole and metronidazole or their combinations for treatment of bacterial vaginosis. METHOD: In an open, randomized, prospective study, 152 patients with bacterial vaginosis according to Amsel's criteria were included into the study. The patients were divided into eight groups: (1) oral ornidazole 2 x 500 mg/day for 5 days; (2) vaginal ornidazole 500 mg/day for 5 days; (3) oral and vaginal ornidazole for 5 days; (4) oral secnidazole 2 g in a single dose; (5) oral secnidazole 2 g in a single dose and vaginal ornidazole 500 mg/day for 5 days; (6) oral secnidazole 2 g in a single dose and vaginal metronidazole 2 x 500 mg/day for 7 days; (7) oral ornidazole 2 x 500 mg/day for 5 days and vaginal metronidazole 2 x 500 mg/day for 7 days; and (8) vaginal metronidazole 2 x 500 mg/day for 7 days. None of the partners received any treatment. RESULT: We found a 100% cure rate in both oral and vaginal ornidazole and oral secnidazole-vaginal metronidazole groups. CONCLUSION: Vaginal treatments including ornidazole and metronidazole are not as effective as both oral and vaginal drug combinations.
Authors:
F Saraçoğlu; K Göl; I Sahin; B Türkkani; C Atalay; C Oztopçu
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  62     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-11-06     Completed Date:  1998-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  59-61     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Numune Hospital, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Administration, Intravaginal
Administration, Oral
Anti-Infective Agents / administration & dosage*
Drug Therapy, Combination
Female
Humans
Metronidazole / administration & dosage,  analogs & derivatives*,  therapeutic use
Ornidazole / administration & dosage*
Recurrence
Treatment Outcome
Vaginosis, Bacterial / drug therapy*
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 16773-42-5/Ornidazole; 3366-95-8/secnidazole; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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