| Treatment of autoinflammatory syndromes. | |
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MedLine Citation:
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PMID: 20966753 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Inherited autoinflammatory diseases are experiments in nature in which mutations of proteins playing a pivotal role in the regulation of the innate immunity lead to unprovoked episodes of inflammation. The understanding of the molecular pathways involved in these disorders has shed a new light on the pattern of activation and maintenance of the inflammatory response and disclosed new molecular therapeutic targets. In this review, we outline the more recent novelties in the treatment of autoinflammatory diseases and their possible implications for some multifactorial pediatric conditions. RECENT FINDINGS: Cryopyrin-associated periodic syndrome (CAPS) represents the prototype of autoinflammatory diseases. The study of the pathophysiological consequence of mutations of the cryopyrin gene (NLRP3) allowed the identification of the intracellular pathways thought to play a pivotal part in the activation and secretion of the potent inflammatory cytokine interleukin (IL)-1β. The dramatic effect of IL-1 blockade in CAPS opens new perspectives for the treatment of other inherited and multifactorial inflammatory disorders. A number of IL-1 blockers are now available on the market. SUMMARY: Studies on the pathogenesis and treatment of inherited autoinflammatory diseases are also changing the approach to some multifactorial inflammatory conditions. |
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Authors:
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Marco Gattorno; Alberto Martini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in pediatrics Volume: 22 ISSN: 1531-698X ISO Abbreviation: Curr. Opin. Pediatr. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-05-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9000850 Medline TA: Curr Opin Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 771-8 Citation Subset: IM |
Affiliation:
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aUO Pediatria II, G. Gaslini Institute, Italy bDepartment of Pediatrics, University of Genova, Genova, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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