| Treatment of autoimmune disease with extracorporeal photochemotherapy: pemphigus vulgaris--preliminary report. | |
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MedLine Citation:
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PMID: 2636804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracorporeal photochemotherapy is a new form of immunotherapy which involves the extracorporeal photoinactivation of peripheral blood cells by 8-methoxypsoralen in the presence of ultraviolet A irradiation, followed by readministration of the cells. To explore the efficacy of this therapy in the treatment of autoimmune disease, four patients with a lengthy history of corticosteroid and immunosuppressive drug-resistant pemphigus vulgaris were initiated on extracorporeal photochemotherapy. Three patients experienced a complete remission in cutaneous disease expression, permitting discontinuation of medications in two and a substantial decrease in the third. Significant reductions in serum antiepidermal cell antibody titers occurred in all four patients. The treatments were well tolerated without the occurrence of adverse events. These results in a small number of patients suggest that extracorporeal photochemotherapy may prove to be a useful tool in the treatment of aggressive autoimmune disease. |
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Authors:
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A H Rook; P W Heald; G T Nahass; W Macey; W K Witmer; G S Lazarus; B V Jegasothy |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Yale journal of biology and medicine Volume: 62 ISSN: 0044-0086 ISO Abbreviation: Yale J Biol Med Publication Date: 1989 Nov-Dec |
Date Detail:
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Created Date: 1990-06-29 Completed Date: 1990-06-29 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0417414 Medline TA: Yale J Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 647-52 Citation Subset: IM |
Affiliation:
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General Clinical Research Center, Hospital of University of Pennsylvania, Philadelphia 19104. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Autoimmune Diseases / therapy Extracorporeal Circulation Female Humans Male Middle Aged PUVA Therapy* Pemphigus / immunology, therapy* T-Lymphocytes / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR00040-29/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Yale J Biol Med Journal ID (pmc): yjbm ISSN: 0044-0086 ISSN: 1551-4056 Publisher: Yale Journal of Biology and Medicine |
Article Information Download PDF  Print publication date: Season: Nov?Dec Year: 1989 Volume: 62 Issue: 6 First Page: 647 Last Page: 652 ID: 2589152 PubMed Id: 2636804 |
| Treatment of autoimmune disease with extracorporeal photochemotherapy: pemphigus vulgaris--preliminary report. | |
| A. H. Rook | |
| P. W. Heald | |
| G. T. Nahass | |
| W. Macey | |
| W. K. Witmer | |
| G. S. Lazarus | |
| B. V. Jegasothy | |
| General Clinical Research Center, Hospital of University of Pennsylvania, Philadelphia 19104. |
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