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Treatment of autoimmune disease with extracorporeal photochemotherapy: pemphigus vulgaris--preliminary report.
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MedLine Citation:
PMID:  2636804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Extracorporeal photochemotherapy is a new form of immunotherapy which involves the extracorporeal photoinactivation of peripheral blood cells by 8-methoxypsoralen in the presence of ultraviolet A irradiation, followed by readministration of the cells. To explore the efficacy of this therapy in the treatment of autoimmune disease, four patients with a lengthy history of corticosteroid and immunosuppressive drug-resistant pemphigus vulgaris were initiated on extracorporeal photochemotherapy. Three patients experienced a complete remission in cutaneous disease expression, permitting discontinuation of medications in two and a substantial decrease in the third. Significant reductions in serum antiepidermal cell antibody titers occurred in all four patients. The treatments were well tolerated without the occurrence of adverse events. These results in a small number of patients suggest that extracorporeal photochemotherapy may prove to be a useful tool in the treatment of aggressive autoimmune disease.
Authors:
A H Rook; P W Heald; G T Nahass; W Macey; W K Witmer; G S Lazarus; B V Jegasothy
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Yale journal of biology and medicine     Volume:  62     ISSN:  0044-0086     ISO Abbreviation:  Yale J Biol Med     Publication Date:    1989 Nov-Dec
Date Detail:
Created Date:  1990-06-29     Completed Date:  1990-06-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417414     Medline TA:  Yale J Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  647-52     Citation Subset:  IM    
Affiliation:
General Clinical Research Center, Hospital of University of Pennsylvania, Philadelphia 19104.
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MeSH Terms
Descriptor/Qualifier:
Aged
Autoimmune Diseases / therapy
Extracorporeal Circulation
Female
Humans
Male
Middle Aged
PUVA Therapy*
Pemphigus / immunology,  therapy*
T-Lymphocytes / drug effects
Grant Support
ID/Acronym/Agency:
M01 RR00040-29/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Yale J Biol Med
Journal ID (pmc): yjbm
ISSN: 0044-0086
ISSN: 1551-4056
Publisher: Yale Journal of Biology and Medicine
Article Information
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Print publication date: Season: Nov?Dec Year: 1989
Volume: 62 Issue: 6
First Page: 647 Last Page: 652
ID: 2589152
PubMed Id: 2636804

Treatment of autoimmune disease with extracorporeal photochemotherapy: pemphigus vulgaris--preliminary report.
A. H. Rook
P. W. Heald
G. T. Nahass
W. Macey
W. K. Witmer
G. S. Lazarus
B. V. Jegasothy
General Clinical Research Center, Hospital of University of Pennsylvania, Philadelphia 19104.



Article Categories:
  • Research Article


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