| Treatment of arteriovenous malformations using Gamma Knife surgery: the experience at the University of Washington from 2000 to 2005. | |
MedLine Citation:
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PMID: 19123888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECT: The purpose of this study was to examine the efficacy and toxicity of treating arteriovenous malformations (AVMs) with the model 3C Gamma Knife at the University of Washington Medical Center. METHODS: Ninety-five evaluable patients with 99 treatable AVMs were treated at the University of Washington Medical Center from April 2000 through June 2005. The median patient age at the time of treatment was 40 years (range 6-68 years). The male to female patient ratio was 0.98:1. The median AVM volume treated was 3.8 cm(3) (range 0.12-32 cm(3)). Forty-four percent of the patients had hemorrhaged prior to treatment. The median peripheral Gamma Knife surgery dose was 20 Gy with a median of 12 isocenters treated. The median follow-up duration was 38 months (range 3-91 months). Eighty-one percent of the patients had no previous stereotactic radiosurgery (SRS), whereas the remaining 19% had previously been treated with linear accelerator-based SRS. RESULTS: The Kaplan-Meier estimated 6-year AVM obliteration rate for the entire cohort was 71.4%. The Kaplan-Meier estimated 6-year obliteration rate was 72% for patients having no prior SRS and 54.5% for those undergoing repeat SRS. The median time to AVM obliteration was 47 months, with 90% of the obliterations occurring between 24 and 58 months. Eight patients (7.4%) experienced late toxicities. There were 2 fatal bleeds and 13 (13.8%) nonfatal bleeds after Gamma Knife surgery. CONCLUSIONS: Gamma Knife surgery is an effective treatment for AVMs, resulting in an excellent obliteration rate with acceptable toxicity. |
Authors:
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James G Douglas; Robert Goodkin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurosurgery Volume: 109 Suppl ISSN: 0022-3085 ISO Abbreviation: J. Neurosurg. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-01-06 Completed Date: 2009-01-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: United States |
Other Details:
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Languages: eng Pagination: 51-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiation Oncology, University of Washington Cancer Center, Seattle, Washington 98195-6043, USA. drjay@u.washington.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Child Cohort Studies Embolization, Therapeutic Female Humans Intracranial Arteriovenous Malformations / complications, diagnosis, surgery* Kaplan-Meiers Estimate Male Middle Aged Radiosurgery* / instrumentation Radiotherapy Dosage Recurrence Retreatment Retrospective Studies Treatment Outcome Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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