Document Detail

Treatment of arteriovenous malformations using Gamma Knife surgery: the experience at the University of Washington from 2000 to 2005.
MedLine Citation:
PMID:  19123888     Owner:  NLM     Status:  MEDLINE    
OBJECT: The purpose of this study was to examine the efficacy and toxicity of treating arteriovenous malformations (AVMs) with the model 3C Gamma Knife at the University of Washington Medical Center. METHODS: Ninety-five evaluable patients with 99 treatable AVMs were treated at the University of Washington Medical Center from April 2000 through June 2005. The median patient age at the time of treatment was 40 years (range 6-68 years). The male to female patient ratio was 0.98:1. The median AVM volume treated was 3.8 cm(3) (range 0.12-32 cm(3)). Forty-four percent of the patients had hemorrhaged prior to treatment. The median peripheral Gamma Knife surgery dose was 20 Gy with a median of 12 isocenters treated. The median follow-up duration was 38 months (range 3-91 months). Eighty-one percent of the patients had no previous stereotactic radiosurgery (SRS), whereas the remaining 19% had previously been treated with linear accelerator-based SRS. RESULTS: The Kaplan-Meier estimated 6-year AVM obliteration rate for the entire cohort was 71.4%. The Kaplan-Meier estimated 6-year obliteration rate was 72% for patients having no prior SRS and 54.5% for those undergoing repeat SRS. The median time to AVM obliteration was 47 months, with 90% of the obliterations occurring between 24 and 58 months. Eight patients (7.4%) experienced late toxicities. There were 2 fatal bleeds and 13 (13.8%) nonfatal bleeds after Gamma Knife surgery. CONCLUSIONS: Gamma Knife surgery is an effective treatment for AVMs, resulting in an excellent obliteration rate with acceptable toxicity.
James G Douglas; Robert Goodkin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  109 Suppl     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-06     Completed Date:  2009-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  51-6     Citation Subset:  AIM; IM    
Department of Radiation Oncology, University of Washington Cancer Center, Seattle, Washington 98195-6043, USA.
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MeSH Terms
Cohort Studies
Embolization, Therapeutic
Intracranial Arteriovenous Malformations / complications,  diagnosis,  surgery*
Kaplan-Meiers Estimate
Middle Aged
Radiosurgery* / instrumentation
Radiotherapy Dosage
Retrospective Studies
Treatment Outcome
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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