Document Detail

Treatment of arteriovenous malformations of the brain.
MedLine Citation:
PMID:  17217851     Owner:  NLM     Status:  MEDLINE    
The treatment of ruptured and unruptured brain arteriovenous malformations (AVMs) is driven by the need to prevent incident or recurrent intracranial hemorrhages. Improving feasibility of the rapidly developing endovascular, neurosurgical, and radiotherapeutic procedures leads to invasive treatment of an increasing number of neurologically intact patients with accidentally diagnosed AVMs. Recent data confirm that the natural history risk of unruptured AVMs is significantly lower than the risk of those presenting with rupture, and the treatment risk of invasive management of unruptured AVMs seems higher than their natural history risk. The treatment decision algorithm for these patients remains unsettled, as no randomized clinical trial data exist on the benefit of invasive AVM treatment for patients with bled or with unbled AVMs. The recently launched study A Randomized Trial of Unruptured Brain AVMs (ARUBA) will be the first trial randomizing patients with nonhemorrhaged AVMs to invasive versus conservative management.
Andreas Hartmann; Henning Mast; Jae H Choi; Christian Stapf; Jay P Mohr
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  7     ISSN:  1528-4042     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-12     Completed Date:  2007-03-06     Revised Date:  2007-12-13    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  28-34     Citation Subset:  IM    
Stroke Unit, Department of Neurology, Charité Hochschulmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
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MeSH Terms
Aneurysm, Ruptured / etiology,  therapy
Arteriovenous Malformations / therapy*
Brain Diseases / therapy*
Cerebral Angiography / methods
Cerebral Hemorrhage / complications,  etiology
Embolization, Therapeutic / methods*
Intracranial Arteriovenous Malformations
Neurosurgical Procedures*
Comment In:
Radiologe. 2007 Aug;47(8):661   [PMID:  17969248 ]

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