Document Detail

Treatment of arteriovenous malformations of the brain with combined embolization and stereotactic radiosurgery: results after 1 and 2 years.
MedLine Citation:
PMID:  2120988     Owner:  NLM     Status:  MEDLINE    
Seven patients with large arteriovenous malformations (AVMs) of the brain were selected for combined therapy with particulate embolization, followed by radiosurgery of the residual nidus. The goal of embolization was to reduce the patient nidus to a size that facilitated successful stereotactic radiosurgery. Angiograms obtained 1 and 2 years after radiosurgery were evaluated for changes in nidus size, flow rate, and feeding and draining vessels. One year after stereotactic radiosurgery, one AVM was angiographically undetectable. Three other AVMs demonstrated a volume reduction of greater than 50%, in addition to decreased shunt speed and altered angioarchitecture at 1-year follow-up. At 2-year follow-ups, two of seven AVMs were cured, and an additional two of seven had a greater than 98% reduction in nidus volume. Although one patient experienced a transient deficit from embolotherapy, none of our patients suffered a new neurologic deficit or a hemorrhage during the follow-up period. Our data support the efficacy of combined embolotherapy and radiosurgery for definitive therapy of selected large AVMs of the brain.
R C Dawson; R W Tarr; S T Hecht; C A Jungreis; L D Lunsford; R Coffey; J A Horton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  11     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:    1990 Sep-Oct
Date Detail:
Created Date:  1990-11-16     Completed Date:  1990-11-16     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  857-64     Citation Subset:  IM    
Department of Radiology, University of Pittsburgh, Presbyterian-University Hospital, PA 15213.
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MeSH Terms
Cerebral Angiography
Combined Modality Therapy
Embolization, Therapeutic*
Follow-Up Studies
Intracranial Arteriovenous Malformations / radiotherapy,  surgery,  therapy*
Middle Aged
Stereotaxic Techniques*
Comment In:
AJNR Am J Neuroradiol. 1991 Sep-Oct;12(5):1023-4   [PMID:  1950898 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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