Document Detail


Treatment of arteriosclerosis.
MedLine Citation:
PMID:  12510249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Summary. Arteriosclerotic disease develops over the course of several decades. Currently, a number of therapies are at hand to effectively stop this process and avoid complications of arteriosclerosis. Among the non-pharmacologic options, a balanced diet and physical activity predominate. A modern dietary plan offers a variety of tasty servings rich in fresh fruit and vegetables, cereals, fish, and poly-unsaturated fatty acids. The value of regular physical activity is demonstrated by the finding that an increase in exercise capacity ("cardiorespiratory fitness") by only one metabolic equivalent already reduces cardiovascular risk by 20-25 %. Regarding pharmacologic therapy, convincing data are available for cholesterol synthase inhibitors ("statins"), some substances which influence the renin-angiotensin system (such as ramipril), and platelet aggregation inhibitors. Statins produce a 20 to 30 % reduction of cardiac death, myocardial infarction, and stroke. In patients with increased cardiovascular risk, the beneficial action of statins is also evident in subjects with low baseline cholesterol values. Apart from the cholesterol-lowering effects, anti-inflammatory and other vasoprotective mechanisms are involved. The angiotensin-converting enzyme inhibitor ramipril has demonstrated that even independent of blood-pressure lowering, cardiovascular events (cardiac death, myocardial infarction, stroke) are substantially reduced in high-risk patients. The effect is in the same order as that of statins. In patients with left-ventricular hypertrophy, the angiotensin-receptor antagonist losartan produces a notable reduction in stroke, independent of its blood-pressure lowering action. Finally, the platelet aggregation inhibitors aspirin and clopidogrel have proven benefit in secondary prevention and, in the case of aspirin, also in primary prevention in cardiovascular high-risk patients. The anti-arteriosclerotic properties of other substances are actively investigated, including calcium channel blockers, betablockers, and novel drug classes. From the medical point of view, a broader use of the well-proven and effective therapies of arteriosclerosis and its complications is clearly warranted.
Authors:
A Schmermund; R Erbel
Related Documents :
12236319 - Prognosis of hypercholesterolemic patients taking pravastatin for five years: the chiba...
15771919 - Electrocardiographic events and cholesterol reduction with pravastatin in patients with...
12665489 - Relation of inflammation and benefit of statins after percutaneous coronary interventions.
1725039 - Hypertension and coronary artery disease: an unsolved problem.
3773179 - High-density lipoprotein cholesterol measurements. a help or hindrance in practical cli...
11453079 - Using the new cholesterol guidelines in everyday practice.
10614809 - Usefulness of the response of flow velocity in the left anterior descending coronary ar...
19480619 - Prevalence of cardiomyopathy in apparently healthy cats.
8624979 - Traumatic tricuspid insufficiency: a case followed for 32 years, with a note on early s...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Deutsche medizinische Wochenschrift (1946)     Volume:  128     ISSN:  0012-0472     ISO Abbreviation:  Dtsch. Med. Wochenschr.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-02     Completed Date:  2003-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0006723     Medline TA:  Dtsch Med Wochenschr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  41-7     Citation Subset:  IM    
Affiliation:
Abteilung für Kardiologie, Universitätsklinikum Essen, Germany. Axel.Schmermund@uni-essen.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Arteriosclerosis / prevention & control,  therapy*
Cholesterol, LDL / blood
Diet
Humans
Physical Fitness
Chemical
Reg. No./Substance:
0/Cholesterol, LDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  [Non-surgical therapy of iatrogenic false aneurysms].
Next Document:  Reliability of different techniques to assess marginal defects of Class II restorations in retrieved...