| Treatment of aplastic anemia with cyclosporin A, methylprednisolone, and antithymocyte globulin. | |
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MedLine Citation:
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PMID: 3492629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-three patients with aplastic anemia (18/23 with severe aplastic anemia) were treated with an immunosuppressive regimen consisting of cyclosporin A (CsA) and methylprednisolone (MP) (n = 7) or CsA, MP, and antithymocyte globulin (ATG; n = 16). Nineteen patients are alive with a follow-up of 4 to 25 months; three patients died of infections and one of a gastrointestinal hemorrhage. Within 3 months, improvement of hematopoiesis was seen in 14 patients (61%). First signs of a response after 23 to 88 days were followed by complete remission in eight patients, partial remission in three patients, and minimal improvement in three patients. Two of the patients with only minimal improvement were treated with a second course of immunosuppression and reached a complete remission and partial remission. Interestingly, remission proved to be dependent on the continued administration of CsA in four of five patients with partial or complete remission who could be evaluated up to now. Thus, CsA must have been effective in the induction and/or maintenance of remission in three patients. This observation is a very strong argument for the role of T cells in the pathogenesis of at least some cases of aplastic anemia and warrants further evaluation of the role of CsA in the treatment of aplastic anemia. |
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Authors:
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N Frickhofen; W Heit; A Raghavachar; F Porzsolt; H Heimpel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Klinische Wochenschrift Volume: 64 ISSN: 0023-2173 ISO Abbreviation: Klin. Wochenschr. Publication Date: 1986 Nov |
Date Detail:
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Created Date: 1987-03-18 Completed Date: 1987-03-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985205R Medline TA: Klin Wochenschr Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 1165-70 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anemia, Aplastic / blood, therapy* Antilymphocyte Serum / therapeutic use* Cyclosporins / therapeutic use* Drug Therapy, Combination Female Follow-Up Studies Hemoglobinometry Humans Leukocyte Count / drug effects Male Methylprednisolone / therapeutic use* Middle Aged Pilot Projects Platelet Count / drug effects T-Lymphocytes / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antilymphocyte Serum; 0/Cyclosporins; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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