Document Detail

Treatment of the antiphospholipid syndrome.
MedLine Citation:
PMID:  11981319     Owner:  NLM     Status:  MEDLINE    
Despite increasing knowledge of the immunology and pathophysiology of the antiphospholipid syndrome, treating this condition remains challenging. Because of a paucity of randomized controlled trials, many of the treatment recommendations are not evidence-based. Retrospective case series suggest that a high level of oral anticoagulation is needed to prevent recurrent thrombosis. The combination of heparin and low-dose aspirin is effective in significantly increasing the chances of a successful pregnancy in woman with recurrent pregnancy failure associated with antiphospholipid antibodies. Primary prevention with aspirin is justified in patients with antiphospholipid antibodies but without a prior history of thrombosis. Interesting and controversial issues in the treatment of the antiphospholipid syndrome include the use of less intensive anticoagulation or antiplatelet agents in some patient subsets, anticoagulation for certain nonstroke neurologic conditions, the role of other agents (hydroxychloroquine, antioxidants), and novel immunomodulatory strategies.
Robert A S Roubey
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  14     ISSN:  1040-8711     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-04-30     Completed Date:  2002-09-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  238-42     Citation Subset:  IM    
Division of Rheumatology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7280, USA.
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MeSH Terms
Abortion, Spontaneous / etiology,  prevention & control
Antiphospholipid Syndrome / complications,  therapy*
Aspirin / therapeutic use
Fibrinolytic Agents / therapeutic use
Nervous System Diseases / drug therapy,  etiology
Thrombosis / drug therapy,  etiology,  prevention & control
Reg. No./Substance:
0/Fibrinolytic Agents; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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