| Treatment of anal human papillomavirus-associated disease: a long term outcome study. | |
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MedLine Citation:
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PMID: 18574114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment for human papillomavirus (HPV)-associated anal canal disease has been unsatisfactory. The objective of our study was to determine the treatment outcome in our cohort with anal HPV disease. Overall, 181 patients were evaluated over a median period of 19.1 months (range = 2.8-125.5). Eighty-eight patients (48.6%) with high-grade anal intraepithelial neoplasia (AIN) and 82 patients (45.3%) with low-grade AIN underwent treatment. One hundred and forty-one patients (77.9%) received laser ablative treatment as an outpatient procedure. The treatment yielded cure, defined as a disease-free state at 12 months after treatment, in 63.0% (114/181). Median time to cure for the cohort was 31.5 months (95% confidence interval: 23.0-40.0). Treatment outcome showed no evidence of being affected by age, sexual preference, history of smoking or presence of high-grade disease. Median time to cure was significantly affected by a positive HIV status (P = 0.02) and the extent (volume) of the disease (P = 0.01). Contrary to the current view that treatment of HPV-related anal disease is difficult, unrewarding due to recurrences and may lead to substantial morbidity, we demonstrate that effective treatment is possible for both low- and high-grade AIN. These findings should help with the general desire to introduce screening for AIN for at-risk groups. |
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Authors:
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M Nathan; N Hickey; L Mayuranathan; S L Vowler; N Singh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of STD & AIDS Volume: 19 ISSN: 0956-4624 ISO Abbreviation: Int J STD AIDS Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-24 Completed Date: 2008-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007917 Medline TA: Int J STD AIDS Country: England |
Other Details:
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Languages: eng Pagination: 445-9 Citation Subset: IM; X |
Affiliation:
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Department of Sexual Health, Homerton University Hospital, London E9 6SR. mayura.nathan@homerton.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anus Diseases / therapy*, virology Anus Neoplasms / pathology, therapy*, virology Carcinoma, Squamous Cell / pathology, therapy*, virology Female Humans Laser Therapy / utilization* Male Middle Aged Papillomaviridae Papillomavirus Infections / complications, therapy*, virology Time Factors Treatment Outcome Warts / therapy*, virology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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