| Treatment of allergic rhinitis and other immunoglobulin E-mediated diseases with anti-immunoglobulin E antibody. | |
| | |
MedLine Citation:
|
PMID: 16722329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Allergic diseases of the airways, including asthma and allergic rhinitis, remain highly prevalent with associated symptoms placing considerable restrictions on the physical, emotional, and social functioning of the affected individual. It is now recognized that immunoglobulin E (IgE) plays a central role in mediating the allergic response that follows exposure to allergens after an initial process of sensitization. This sensitization process results in the overproduction of antigen-specific IgE. Omalizumab, a recombinant humanized monoclonal antibody, is the first therapeutic agent specifically targeting IgE. It has been investigated extensively in the treatment of patients with allergic diseases and is approved in the United States only for the treatment of patients with moderate-to-severe persistent asthma. Although not currently approved by the Food and Drug Administration for this specific indication, omalizumab also has been shown to be effective in patients with seasonal and perennial allergic rhinitis. As expected with a systemic anti-IgE agent, omalizumab also has been found to be helpful in the treatment of patients with concomitant asthma and allergic rhinitis. The efficacy of omalizumab in a range of allergic diseases reaffirms the importance of IgE in the pathogenesis of these conditions and shows the potential benefit to be obtained by inhibiting IgE, especially in patients with more severe and comorbid allergic diseases. |
| | |
Authors:
|
William E Berger |
Related Documents
:
|
16426249 - Association between neopterin in cord blood, urinary neopterin in early childhood and t... 18940139 - Strategies for primary prevention of atopy in children. 19160939 - Exploring the distal lung: new direction in asthma. 6739379 - What is atopy? sidestepping semantics. 18431989 - Diagnostic criteria for house dust mites sensitized allergic patients. 21990499 - Bilateral inferior petrosal sinus sampling. 970229 - A validation of cause-of-death certification in 1,156 deaths. 23140039 - The validity of peak nasal inspiratory flow as a screening tool for nasal obstruction. 17554699 - Association of serotypes of streptococcus pneumoniae with disease severity and outcome ... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Review |
Journal Detail:
|
Title: Allergy and asthma proceedings : the official journal of regional and state allergy societies Volume: 27 ISSN: 1088-5412 ISO Abbreviation: Allergy Asthma Proc Publication Date: 2006 Mar-Apr |
Date Detail:
|
Created Date: 2006-05-25 Completed Date: 2006-07-17 Revised Date: 2013-01-18 |
Medline Journal Info:
|
Nlm Unique ID: 9603640 Medline TA: Allergy Asthma Proc Country: United States |
Other Details:
|
Languages: eng Pagination: S29-32 Citation Subset: IM |
Affiliation:
|
Mission Viejo Medical Center, Mission Viejo, California 92691, USA. weberger@uci.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antibodies, Anti-Idiotypic
/
therapeutic use* Antibodies, Monoclonal / therapeutic use* Antibodies, Monoclonal, Humanized Dose-Response Relationship, Drug Drug Administration Schedule Female Humans Hypersensitivity, Immediate / diagnosis, drug therapy* Male Prognosis Rhinitis, Allergic, Perennial / diagnosis, drug therapy* Risk Assessment Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Anti-Idiotypic; 0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/anti-IgE antibodies; 0/omalizumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Treatment of asthma with anti-immunoglobulin E monoclonal antibody.
Next Document: Anti-immunoglobulin E monoclonal antibody administered with immunotherapy.