Document Detail

Treatment of adult gonococcal keratoconjunctivitis with oral norfloxacin.
MedLine Citation:
PMID:  2510519     Owner:  NLM     Status:  MEDLINE    
We evaluated the efficacy of oral norfloxacin in 15 patients with culture-proven gonococcal eye disease caused by Neisseria gonorrhoeae. The first seven patients received 1,200 mg of oral norfloxacin for three consecutive days. The other eight patients were each treated with a single oral dose of 1,200 mg of norfloxacin. All control cultures were negative, and there was no progression of the corneal lesions after treatment was initiated. No adverse effects were observed. The results of this study suggested that a single dose of oral norfloxacin may be a valuable alternative to the currently recommended treatment regimens for gonococcal eye disease because it combines high efficacy and low toxicity with low cost and excellent patient compliance.
P Kestelyn; J Bogaerts; A M Stevens; P Piot; A Meheus
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  108     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-08     Completed Date:  1989-12-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  516-23     Citation Subset:  AIM; IM    
Department of Ophthalmology, Centre Hospitalier de Kigali, Rwanda.
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MeSH Terms
Administration, Oral
Clinical Trials as Topic
Conjunctiva / microbiology
Eye Infections, Bacterial / drug therapy*,  etiology,  pathology
Follow-Up Studies
Keratoconjunctivitis / drug therapy*,  etiology,  pathology
Neisseria gonorrhoeae / isolation & purification*
Norfloxacin / administration & dosage,  therapeutic use*
Urethra / microbiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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